ATR is required to complete meiotic recombination in mice

ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

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Autores principales:	Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés, Ignasi Roig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe3547f3e3bf408bb594225884c01810
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spelling	oai:doaj.org-article:fe3547f3e3bf408bb594225884c018102021-12-02T16:49:39ZATR is required to complete meiotic recombination in mice10.1038/s41467-018-04851-z2041-1723https://doaj.org/article/fe3547f3e3bf408bb594225884c018102018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04851-zhttps://doaj.org/toc/2041-1723ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.Sarai PachecoAndros Maldonado-LinaresMarina Marcet-OrtegaCristina RojasAna Martínez-MarchalJudit Fuentes-LazaroJulian LangeMaria JasinScott KeeneyOscar Fernández-CapetilloMontserrat Garcia-CaldésIgnasi RoigNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarai Pacheco Andros Maldonado-Linares Marina Marcet-Ortega Cristina Rojas Ana Martínez-Marchal Judit Fuentes-Lazaro Julian Lange Maria Jasin Scott Keeney Oscar Fernández-Capetillo Montserrat Garcia-Caldés Ignasi Roig ATR is required to complete meiotic recombination in mice
description	ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.
format	article
author	Sarai Pacheco Andros Maldonado-Linares Marina Marcet-Ortega Cristina Rojas Ana Martínez-Marchal Judit Fuentes-Lazaro Julian Lange Maria Jasin Scott Keeney Oscar Fernández-Capetillo Montserrat Garcia-Caldés Ignasi Roig
author_facet	Sarai Pacheco Andros Maldonado-Linares Marina Marcet-Ortega Cristina Rojas Ana Martínez-Marchal Judit Fuentes-Lazaro Julian Lange Maria Jasin Scott Keeney Oscar Fernández-Capetillo Montserrat Garcia-Caldés Ignasi Roig
author_sort	Sarai Pacheco
title	ATR is required to complete meiotic recombination in mice
title_short	ATR is required to complete meiotic recombination in mice
title_full	ATR is required to complete meiotic recombination in mice
title_fullStr	ATR is required to complete meiotic recombination in mice
title_full_unstemmed	ATR is required to complete meiotic recombination in mice
title_sort	atr is required to complete meiotic recombination in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe3547f3e3bf408bb594225884c01810
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ATR is required to complete meiotic recombination in mice

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