Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure.
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Nature Portfolio
2021
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oai:doaj.org-article:fe3711b0c9be44609d25d2ed5e1f23442021-12-02T19:04:19ZPhospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy10.1038/s41467-021-25439-02041-1723https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f23442021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25439-0https://doaj.org/toc/2041-1723Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure.Niels Grote BeverborgDaniela SpäterRalph KnöllAlejandro HidalgoSteve T. YehZaher ElbeckHerman H. W. SilljéTim R. EijgenraamHumam SigaMagdalena ZurekMalin PalmérSusanne PehrssonTamsin AlberyNils BomerMartijn F. HoesCornelis J. BoogerdMichael FriskEva van RooijSagar DamleWilliam E. LouchQing-Dong WangRegina Fritsche-DanielsonKenneth R. ChienKenny M. HanssonAdam E. MullickRudolf A. de BoerPeter van der MeerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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EN |
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Science Q |
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Science Q Niels Grote Beverborg Daniela Später Ralph Knöll Alejandro Hidalgo Steve T. Yeh Zaher Elbeck Herman H. W. Silljé Tim R. Eijgenraam Humam Siga Magdalena Zurek Malin Palmér Susanne Pehrsson Tamsin Albery Nils Bomer Martijn F. Hoes Cornelis J. Boogerd Michael Frisk Eva van Rooij Sagar Damle William E. Louch Qing-Dong Wang Regina Fritsche-Danielson Kenneth R. Chien Kenny M. Hansson Adam E. Mullick Rudolf A. de Boer Peter van der Meer Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| description |
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure. |
| format |
article |
| author |
Niels Grote Beverborg Daniela Später Ralph Knöll Alejandro Hidalgo Steve T. Yeh Zaher Elbeck Herman H. W. Silljé Tim R. Eijgenraam Humam Siga Magdalena Zurek Malin Palmér Susanne Pehrsson Tamsin Albery Nils Bomer Martijn F. Hoes Cornelis J. Boogerd Michael Frisk Eva van Rooij Sagar Damle William E. Louch Qing-Dong Wang Regina Fritsche-Danielson Kenneth R. Chien Kenny M. Hansson Adam E. Mullick Rudolf A. de Boer Peter van der Meer |
| author_facet |
Niels Grote Beverborg Daniela Später Ralph Knöll Alejandro Hidalgo Steve T. Yeh Zaher Elbeck Herman H. W. Silljé Tim R. Eijgenraam Humam Siga Magdalena Zurek Malin Palmér Susanne Pehrsson Tamsin Albery Nils Bomer Martijn F. Hoes Cornelis J. Boogerd Michael Frisk Eva van Rooij Sagar Damle William E. Louch Qing-Dong Wang Regina Fritsche-Danielson Kenneth R. Chien Kenny M. Hansson Adam E. Mullick Rudolf A. de Boer Peter van der Meer |
| author_sort |
Niels Grote Beverborg |
| title |
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| title_short |
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| title_full |
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| title_fullStr |
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| title_full_unstemmed |
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| title_sort |
phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f2344 |
| work_keys_str_mv |
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