Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic neurons in the dorsal motor nucleus of the vagus an...

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Autores principales:	Eunjin Kwon, Hye-Young Joung, Shun-Mei Liu, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe3b417b3e654fd0a95ad82351d23a97
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spelling	oai:doaj.org-article:fe3b417b3e654fd0a95ad82351d23a972021-12-02T13:27:23ZOptogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production10.1038/s41467-020-20160-w2041-1723https://doaj.org/article/fe3b417b3e654fd0a95ad82351d23a972020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20160-whttps://doaj.org/toc/2041-1723Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic neurons in the dorsal motor nucleus of the vagus and that stimulation of this pathway elevates blood glucose levelsEunjin KwonHye-Young JoungShun-Mei LiuStreamson C. ChuaGary J. SchwartzYoung-Hwan JoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunjin Kwon Hye-Young Joung Shun-Mei Liu Streamson C. Chua Gary J. Schwartz Young-Hwan Jo Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
description	Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic neurons in the dorsal motor nucleus of the vagus and that stimulation of this pathway elevates blood glucose levels
format	article
author	Eunjin Kwon Hye-Young Joung Shun-Mei Liu Streamson C. Chua Gary J. Schwartz Young-Hwan Jo
author_facet	Eunjin Kwon Hye-Young Joung Shun-Mei Liu Streamson C. Chua Gary J. Schwartz Young-Hwan Jo
author_sort	Eunjin Kwon
title	Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
title_short	Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
title_full	Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
title_fullStr	Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
title_full_unstemmed	Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
title_sort	optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fe3b417b3e654fd0a95ad82351d23a97
work_keys_str_mv	AT eunjinkwon optogeneticstimulationoftheliverprojectingmelanocortinergicpathwaypromoteshepaticglucoseproduction AT hyeyoungjoung optogeneticstimulationoftheliverprojectingmelanocortinergicpathwaypromoteshepaticglucoseproduction AT shunmeiliu optogeneticstimulationoftheliverprojectingmelanocortinergicpathwaypromoteshepaticglucoseproduction AT streamsoncchua optogeneticstimulationoftheliverprojectingmelanocortinergicpathwaypromoteshepaticglucoseproduction AT garyjschwartz optogeneticstimulationoftheliverprojectingmelanocortinergicpathwaypromoteshepaticglucoseproduction AT younghwanjo optogeneticstimulationoftheliverprojectingmelanocortinergicpathwaypromoteshepaticglucoseproduction
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Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

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