A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study

Qingwei Liu1, Yu Cai1, Weili Lin2, Gregory H Turner3, Hongyu An21Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA; 2Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA; 3Neuroimaging Research, Ba...

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Autores principales:	Cai Y, Liu Q, An H, Turner GH, Lin W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/fe3dfd57d275463894014285e820ff44
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spelling	oai:doaj.org-article:fe3dfd57d275463894014285e820ff442021-12-02T08:46:07ZA magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study1179-1470https://doaj.org/article/fe3dfd57d275463894014285e820ff442012-03-01T00:00:00Zhttp://www.dovepress.com/a-magnetic-resonance-mr-compatible-selective-brain-temperature-manipul-a9420https://doaj.org/toc/1179-1470Qingwei Liu1, Yu Cai1, Weili Lin2, Gregory H Turner3, Hongyu An21Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA; 2Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA; 3Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, USAAbstract: There is overwhelming evidence that hypothermia can improve the outcome of an ischemic stroke. However, the most widely used systemic cooling method could lead to multiple side effects, while the incompatibility with magnetic resonance imaging of the present selective cooling methods highly limit their application in preclinical studies. In this study, we developed a magnetic resonance compatible selective brain temperature manipulation system for small animals, which can regulate brain temperature quickly and accurately for a desired period of time, while maintaining the normal body physiological conditions. This device was utilized to examine the relationship between T1 relaxation, cerebral blood flow, and temperature in brain tissue during magnetic resonance imaging of ischemic stroke. The results showed that this device can be an efficient brain temperature manipulation tool for preclinical studies needing local hypothermic or hyperthermic conditions.Keywords: selective brain cooling, hyperthermia, hypothermia, brain temperature mapping, ischemic strokeCai YLiu QAn HTurner GHLin WDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2012, Iss default, Pp 13-22 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Cai Y Liu Q An H Turner GH Lin W A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study
description	Qingwei Liu1, Yu Cai1, Weili Lin2, Gregory H Turner3, Hongyu An21Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA; 2Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, USA; 3Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, USAAbstract: There is overwhelming evidence that hypothermia can improve the outcome of an ischemic stroke. However, the most widely used systemic cooling method could lead to multiple side effects, while the incompatibility with magnetic resonance imaging of the present selective cooling methods highly limit their application in preclinical studies. In this study, we developed a magnetic resonance compatible selective brain temperature manipulation system for small animals, which can regulate brain temperature quickly and accurately for a desired period of time, while maintaining the normal body physiological conditions. This device was utilized to examine the relationship between T1 relaxation, cerebral blood flow, and temperature in brain tissue during magnetic resonance imaging of ischemic stroke. The results showed that this device can be an efficient brain temperature manipulation tool for preclinical studies needing local hypothermic or hyperthermic conditions.Keywords: selective brain cooling, hyperthermia, hypothermia, brain temperature mapping, ischemic stroke
format	article
author	Cai Y Liu Q An H Turner GH Lin W
author_facet	Cai Y Liu Q An H Turner GH Lin W
author_sort	Cai Y
title	A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study
title_short	A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study
title_full	A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study
title_fullStr	A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study
title_full_unstemmed	A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study
title_sort	magnetic resonance (mr) compatible selective brain temperature manipulation system for preclinical study
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/fe3dfd57d275463894014285e820ff44
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_version_	1718398401555464192

A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study

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