Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile

Abstract Choroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several c...

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Autores principales:	Young Ho Kim, Boram Lee, Edward Kang, Jaeryung Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe3ecb68ac8b4b23848405d2dda41632
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spelling	oai:doaj.org-article:fe3ecb68ac8b4b23848405d2dda416322021-12-02T15:54:02ZClustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile10.1038/s41598-021-84650-72045-2322https://doaj.org/article/fe3ecb68ac8b4b23848405d2dda416322021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84650-7https://doaj.org/toc/2045-2322Abstract Choroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several clusters according to choroidal profiles based on subfoveal choroidal thickness (CT), peripapillary CT, the ratio of subfoveal CT to peripapillary CT and age. We retrospectively analyzed 661 eyes, including 190 normal controls and 471 with AMD or PSDs. In the AMD groups, eyes with soft drusen or reticular pseudodrusen were belonged to the same cluster as those with classic exudative AMD (all p < 0.001). However, eyes with pachydrusen were not clustered with eyes from other AMD groups; instead, they were classified in the same cluster as eyes from the PSD group (all p < 0.001). In the PSD group, eyes with pachychoroid neovasculopathy were grouped in the same cluster of those with polypoidal choroidal vasculopathy (p < 0.001). The cluster analysis based on the CT profiles, including subfoveal CT, peripapillary CT, and their ratio, revealed a clustering pattern of eyes with AMD and PSDs. These findings support the suggestion that pachydrusen has the common pathogenesis as PSD.Young Ho KimBoram LeeEdward KangJaeryung OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young Ho Kim Boram Lee Edward Kang Jaeryung Oh Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
description	Abstract Choroidal changes have been suggested to be involved in the pathophysiology of both age-related macular degeneration (AMD) and pachychoroid spectrum diseases (PSD). To find out the choroidal characteristics of each disease groups, various groups of AMD and PSD were classified into several clusters according to choroidal profiles based on subfoveal choroidal thickness (CT), peripapillary CT, the ratio of subfoveal CT to peripapillary CT and age. We retrospectively analyzed 661 eyes, including 190 normal controls and 471 with AMD or PSDs. In the AMD groups, eyes with soft drusen or reticular pseudodrusen were belonged to the same cluster as those with classic exudative AMD (all p < 0.001). However, eyes with pachydrusen were not clustered with eyes from other AMD groups; instead, they were classified in the same cluster as eyes from the PSD group (all p < 0.001). In the PSD group, eyes with pachychoroid neovasculopathy were grouped in the same cluster of those with polypoidal choroidal vasculopathy (p < 0.001). The cluster analysis based on the CT profiles, including subfoveal CT, peripapillary CT, and their ratio, revealed a clustering pattern of eyes with AMD and PSDs. These findings support the suggestion that pachydrusen has the common pathogenesis as PSD.
format	article
author	Young Ho Kim Boram Lee Edward Kang Jaeryung Oh
author_facet	Young Ho Kim Boram Lee Edward Kang Jaeryung Oh
author_sort	Young Ho Kim
title	Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
title_short	Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
title_full	Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
title_fullStr	Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
title_full_unstemmed	Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
title_sort	clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe3ecb68ac8b4b23848405d2dda41632
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Clustering of eyes with age-related macular degeneration or pachychoroid spectrum diseases based on choroidal thickness profile

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