FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population

Abstract Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk of type 2 diabetes (DM), therefore, early diagnosis of NAFLD is important to prevent incident DM. FIB-4 index, a biomarker, often used to evaluate severity of NAFLD, may be useful to evaluate risk for incident DM in or...

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Autores principales:	Tomoyuki Fujita, Makoto Daimon, Satoru Mizushiri, Yuki Nishiya, Hiroshi Murakami, Jutaro Tanabe, Yuki Matsuhashi, Miyuki Yanagimachi, Itoyo Tokuda, Kaori Sawada, Kazushige Ihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe4066d0942946bdbb59e5a68b1ed913
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spelling	oai:doaj.org-article:fe4066d0942946bdbb59e5a68b1ed9132021-12-02T18:48:01ZFIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population10.1038/s41598-020-72894-82045-2322https://doaj.org/article/fe4066d0942946bdbb59e5a68b1ed9132020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72894-8https://doaj.org/toc/2045-2322Abstract Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk of type 2 diabetes (DM), therefore, early diagnosis of NAFLD is important to prevent incident DM. FIB-4 index, a biomarker, often used to evaluate severity of NAFLD, may be useful to evaluate risk for incident DM in ordinary clinical setting. Here, we determined the association of FIB-4 index with changes in indices representing glucose metabolism with aging in a non-diabetic population. From among the participants of the population-based Iwaki study of Japanese people conducted during 2014–2017, 1,268 non-diabetic individuals with complete data sets (age: 51.4 ± 15.9 years; men/women: 485/773) were enrolled in a cross-sectional study. In addition, of the participants, 439 who attended consecutive appointments between 2014 and 2017 were enrolled in a longitudinal study that aimed to evaluate the changes in insulin secretion and resistance with aging (age: 53.1 ± 13.7 years; men/women: 178/261). The cross-sectional study showed significant correlations of FIB-4 index with homeostasis model of assessment (HOMA) indices, even after adjustment for multiple factors (HOMA-β: β = − 0.254, p < 0.001; HOMA-R: β = − 0.247, p < 0.001). The longitudinal study showed a significant association between FIB-4 index and the change in HOMA-β (p < 0.001) but not HOMA-R (p = 0.639) during the 3-year study period. Use of the optimal cut-off value of the FIB-4 index for the prediction of decreased insulin secretion (HOMA-β < 30), determined using receiver operating characteristic analysis (1.592), showed that individuals at risk had a hazard ratio of 2.22 (confidence interval 1.17−4.06) for decreased insulin secretion, after adjustment for confounders. FIB-4 index may represent a useful predictor of a subsequent decrease in insulin secretion, at least in a non-diabetic Japanese population.Tomoyuki FujitaMakoto DaimonSatoru MizushiriYuki NishiyaHiroshi MurakamiJutaro TanabeYuki MatsuhashiMiyuki YanagimachiItoyo TokudaKaori SawadaKazushige IharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoyuki Fujita Makoto Daimon Satoru Mizushiri Yuki Nishiya Hiroshi Murakami Jutaro Tanabe Yuki Matsuhashi Miyuki Yanagimachi Itoyo Tokuda Kaori Sawada Kazushige Ihara FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population
description	Abstract Non-alcoholic fatty liver disease (NAFLD) is associated with a high risk of type 2 diabetes (DM), therefore, early diagnosis of NAFLD is important to prevent incident DM. FIB-4 index, a biomarker, often used to evaluate severity of NAFLD, may be useful to evaluate risk for incident DM in ordinary clinical setting. Here, we determined the association of FIB-4 index with changes in indices representing glucose metabolism with aging in a non-diabetic population. From among the participants of the population-based Iwaki study of Japanese people conducted during 2014–2017, 1,268 non-diabetic individuals with complete data sets (age: 51.4 ± 15.9 years; men/women: 485/773) were enrolled in a cross-sectional study. In addition, of the participants, 439 who attended consecutive appointments between 2014 and 2017 were enrolled in a longitudinal study that aimed to evaluate the changes in insulin secretion and resistance with aging (age: 53.1 ± 13.7 years; men/women: 178/261). The cross-sectional study showed significant correlations of FIB-4 index with homeostasis model of assessment (HOMA) indices, even after adjustment for multiple factors (HOMA-β: β = − 0.254, p < 0.001; HOMA-R: β = − 0.247, p < 0.001). The longitudinal study showed a significant association between FIB-4 index and the change in HOMA-β (p < 0.001) but not HOMA-R (p = 0.639) during the 3-year study period. Use of the optimal cut-off value of the FIB-4 index for the prediction of decreased insulin secretion (HOMA-β < 30), determined using receiver operating characteristic analysis (1.592), showed that individuals at risk had a hazard ratio of 2.22 (confidence interval 1.17−4.06) for decreased insulin secretion, after adjustment for confounders. FIB-4 index may represent a useful predictor of a subsequent decrease in insulin secretion, at least in a non-diabetic Japanese population.
format	article
author	Tomoyuki Fujita Makoto Daimon Satoru Mizushiri Yuki Nishiya Hiroshi Murakami Jutaro Tanabe Yuki Matsuhashi Miyuki Yanagimachi Itoyo Tokuda Kaori Sawada Kazushige Ihara
author_facet	Tomoyuki Fujita Makoto Daimon Satoru Mizushiri Yuki Nishiya Hiroshi Murakami Jutaro Tanabe Yuki Matsuhashi Miyuki Yanagimachi Itoyo Tokuda Kaori Sawada Kazushige Ihara
author_sort	Tomoyuki Fujita
title	FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population
title_short	FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population
title_full	FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population
title_fullStr	FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population
title_full_unstemmed	FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population
title_sort	fib-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic japanese population
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fe4066d0942946bdbb59e5a68b1ed913
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FIB-4 index is a marker for a subsequent decrease in insulin secretion in a non-diabetic Japanese population

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