Viral infection in thymoma and thymic tumors with autoimmune diseases

Abstract A thymoma is a type of thymic tumor which is rarely malignant that is frequently reported in adult patients. A number of thymoma‐related immune disorders are observed including autoimmune diseases, which suggests a strong connection between thymoma development and immunological mechanisms....

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Autores principales:	Rui Chang, Shuning Duan, Shicong Li, Peng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	autoimmune diseases infection thymoma virus Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fe409f5d3ce4402bad03b738f2b97b0b
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spelling	oai:doaj.org-article:fe409f5d3ce4402bad03b738f2b97b0b2021-11-14T23:28:25ZViral infection in thymoma and thymic tumors with autoimmune diseases1759-77141759-770610.1111/1759-7714.14157https://doaj.org/article/fe409f5d3ce4402bad03b738f2b97b0b2021-11-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14157https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract A thymoma is a type of thymic tumor which is rarely malignant that is frequently reported in adult patients. A number of thymoma‐related immune disorders are observed including autoimmune diseases, which suggests a strong connection between thymoma development and immunological mechanisms. Characterized by association with humoral and cellular immunodeficiency, thymoma patients are susceptible to opportunistic infections by environmental factors. Recent reports have suggested that viral infection may play a role in the etiological mechanisms of thymoma development associated with dysregulated immunity. In this review, we summarize the case reports and studies related to viral infection, such as CMV, EBV and HSV, that probably play a part in the pathogenesis of thymoma and related diseases. Furthermore, we demonstrate the underlying mechanisms by which viruses may induce the occurrence of thymoma with autoimmune diseases. Lastly, we discuss the potential application of antiviral therapy in the treatment of thymic diseases.Rui ChangShuning DuanShicong LiPeng ZhangWileyarticleautoimmune diseasesinfectionthymomavirusNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 22, Pp 2971-2980 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmune diseases infection thymoma virus Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	autoimmune diseases infection thymoma virus Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Rui Chang Shuning Duan Shicong Li Peng Zhang Viral infection in thymoma and thymic tumors with autoimmune diseases
description	Abstract A thymoma is a type of thymic tumor which is rarely malignant that is frequently reported in adult patients. A number of thymoma‐related immune disorders are observed including autoimmune diseases, which suggests a strong connection between thymoma development and immunological mechanisms. Characterized by association with humoral and cellular immunodeficiency, thymoma patients are susceptible to opportunistic infections by environmental factors. Recent reports have suggested that viral infection may play a role in the etiological mechanisms of thymoma development associated with dysregulated immunity. In this review, we summarize the case reports and studies related to viral infection, such as CMV, EBV and HSV, that probably play a part in the pathogenesis of thymoma and related diseases. Furthermore, we demonstrate the underlying mechanisms by which viruses may induce the occurrence of thymoma with autoimmune diseases. Lastly, we discuss the potential application of antiviral therapy in the treatment of thymic diseases.
format	article
author	Rui Chang Shuning Duan Shicong Li Peng Zhang
author_facet	Rui Chang Shuning Duan Shicong Li Peng Zhang
author_sort	Rui Chang
title	Viral infection in thymoma and thymic tumors with autoimmune diseases
title_short	Viral infection in thymoma and thymic tumors with autoimmune diseases
title_full	Viral infection in thymoma and thymic tumors with autoimmune diseases
title_fullStr	Viral infection in thymoma and thymic tumors with autoimmune diseases
title_full_unstemmed	Viral infection in thymoma and thymic tumors with autoimmune diseases
title_sort	viral infection in thymoma and thymic tumors with autoimmune diseases
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/fe409f5d3ce4402bad03b738f2b97b0b
work_keys_str_mv	AT ruichang viralinfectioninthymomaandthymictumorswithautoimmunediseases AT shuningduan viralinfectioninthymomaandthymictumorswithautoimmunediseases AT shicongli viralinfectioninthymomaandthymictumorswithautoimmunediseases AT pengzhang viralinfectioninthymomaandthymictumorswithautoimmunediseases
_version_	1718429023294455808

Viral infection in thymoma and thymic tumors with autoimmune diseases

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