Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.

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Autores principales: Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin, Martin Guilliams
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/fe465a1e14fb4c67be69745568b1a073
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spelling oai:doaj.org-article:fe465a1e14fb4c67be69745568b1a0732021-12-02T14:38:35ZBone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells10.1038/ncomms103212041-1723https://doaj.org/article/fe465a1e14fb4c67be69745568b1a0732016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10321https://doaj.org/toc/2041-1723Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.Charlotte L. ScottFang ZhengPatrick De BaetselierLiesbet MartensYvan SaeysSofie De PrijckSaskia LippensChloé AbelsSteve SchoonoogheGeert RaesNick DevoogdtBart N. LambrechtAlain BeschinMartin GuilliamsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Charlotte L. Scott
Fang Zheng
Patrick De Baetselier
Liesbet Martens
Yvan Saeys
Sofie De Prijck
Saskia Lippens
Chloé Abels
Steve Schoonooghe
Geert Raes
Nick Devoogdt
Bart N. Lambrecht
Alain Beschin
Martin Guilliams
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
description Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.
format article
author Charlotte L. Scott
Fang Zheng
Patrick De Baetselier
Liesbet Martens
Yvan Saeys
Sofie De Prijck
Saskia Lippens
Chloé Abels
Steve Schoonooghe
Geert Raes
Nick Devoogdt
Bart N. Lambrecht
Alain Beschin
Martin Guilliams
author_facet Charlotte L. Scott
Fang Zheng
Patrick De Baetselier
Liesbet Martens
Yvan Saeys
Sofie De Prijck
Saskia Lippens
Chloé Abels
Steve Schoonooghe
Geert Raes
Nick Devoogdt
Bart N. Lambrecht
Alain Beschin
Martin Guilliams
author_sort Charlotte L. Scott
title Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
title_short Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
title_full Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
title_fullStr Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
title_full_unstemmed Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
title_sort bone marrow-derived monocytes give rise to self-renewing and fully differentiated kupffer cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/fe465a1e14fb4c67be69745568b1a073
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