Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.
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Nature Portfolio
2016
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oai:doaj.org-article:fe465a1e14fb4c67be69745568b1a0732021-12-02T14:38:35ZBone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells10.1038/ncomms103212041-1723https://doaj.org/article/fe465a1e14fb4c67be69745568b1a0732016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10321https://doaj.org/toc/2041-1723Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.Charlotte L. ScottFang ZhengPatrick De BaetselierLiesbet MartensYvan SaeysSofie De PrijckSaskia LippensChloé AbelsSteve SchoonoogheGeert RaesNick DevoogdtBart N. LambrechtAlain BeschinMartin GuilliamsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q |
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Science Q Charlotte L. Scott Fang Zheng Patrick De Baetselier Liesbet Martens Yvan Saeys Sofie De Prijck Saskia Lippens Chloé Abels Steve Schoonooghe Geert Raes Nick Devoogdt Bart N. Lambrecht Alain Beschin Martin Guilliams Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells |
description |
Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts. |
format |
article |
author |
Charlotte L. Scott Fang Zheng Patrick De Baetselier Liesbet Martens Yvan Saeys Sofie De Prijck Saskia Lippens Chloé Abels Steve Schoonooghe Geert Raes Nick Devoogdt Bart N. Lambrecht Alain Beschin Martin Guilliams |
author_facet |
Charlotte L. Scott Fang Zheng Patrick De Baetselier Liesbet Martens Yvan Saeys Sofie De Prijck Saskia Lippens Chloé Abels Steve Schoonooghe Geert Raes Nick Devoogdt Bart N. Lambrecht Alain Beschin Martin Guilliams |
author_sort |
Charlotte L. Scott |
title |
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells |
title_short |
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells |
title_full |
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells |
title_fullStr |
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells |
title_full_unstemmed |
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells |
title_sort |
bone marrow-derived monocytes give rise to self-renewing and fully differentiated kupffer cells |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/fe465a1e14fb4c67be69745568b1a073 |
work_keys_str_mv |
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