Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.

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Detalles Bibliográficos
Autores principales: Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin, Martin Guilliams
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/fe465a1e14fb4c67be69745568b1a073
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