Herbal antioxidants and renal ischemic-reperfusion injury; an updated review

Renal ischemia-reperfusion (RIR) is a pathological condition due to transient restriction of blood flow to the kidneys, which is followed by the subsequent recovery of perfusion and re-oxygenation. RIR injury contributes to the progression of renal dysfunction including acute kidney injury (AKI) in...

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Autores principales:	Masoumeh Asgharpour, Audrey Tolouian, Lakkakula VKS Bhaskar, Ramin Tolouian, Nilofar Massoudi
Formato:	article
Lenguaje:	EN
Publicado:	Society of Diabetic Nephropathy Prevention 2021
Materias:	acute kidney injury renal ischemia-reperfusion oxidative stress antioxidant Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/fe49295c18ce45479ed797075926d4c2
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spelling	oai:doaj.org-article:fe49295c18ce45479ed797075926d4c22021-11-17T08:13:57ZHerbal antioxidants and renal ischemic-reperfusion injury; an updated review2345-420210.34172/npj.2021.03https://doaj.org/article/fe49295c18ce45479ed797075926d4c22021-01-01T00:00:00Zhttps://jnephropharmacology.com/PDF/npj-8317https://doaj.org/toc/2345-4202Renal ischemia-reperfusion (RIR) is a pathological condition due to transient restriction of blood flow to the kidneys, which is followed by the subsequent recovery of perfusion and re-oxygenation. RIR injury contributes to the progression of renal dysfunction including acute kidney injury (AKI) in native and renal allograft transplant. The generation of reactive oxygen species (ROS) during oxidative stress contributes to the occurrence of RIR. Hence, the use of antioxidant compounds can improve oxidative stress due to RIR. This review highlights herbal antioxidant efficacy against RIR injury. The findings of this study indicate that antioxidant compounds with herbal origin could reduce complications due to oxidative stress related to RIR through diminishing lipid peroxidation, decreased production of malondialdehyde (MDA), apoptosis and increasing antioxidant enzymes activity. Reducing oxidative stress with the pharmacological approach of antioxidants can be a desirable target for ameliorating RIR.Masoumeh AsgharpourAudrey TolouianLakkakula VKS BhaskarRamin TolouianNilofar MassoudiSociety of Diabetic Nephropathy Prevention articleacute kidney injuryrenal ischemia-reperfusionoxidative stressantioxidantTherapeutics. PharmacologyRM1-950Diseases of the genitourinary system. UrologyRC870-923ENJournal of Nephropharmacology, Vol 10, Iss 1, Pp e03-e03 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute kidney injury renal ischemia-reperfusion oxidative stress antioxidant Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923
spellingShingle	acute kidney injury renal ischemia-reperfusion oxidative stress antioxidant Therapeutics. Pharmacology RM1-950 Diseases of the genitourinary system. Urology RC870-923 Masoumeh Asgharpour Audrey Tolouian Lakkakula VKS Bhaskar Ramin Tolouian Nilofar Massoudi Herbal antioxidants and renal ischemic-reperfusion injury; an updated review
description	Renal ischemia-reperfusion (RIR) is a pathological condition due to transient restriction of blood flow to the kidneys, which is followed by the subsequent recovery of perfusion and re-oxygenation. RIR injury contributes to the progression of renal dysfunction including acute kidney injury (AKI) in native and renal allograft transplant. The generation of reactive oxygen species (ROS) during oxidative stress contributes to the occurrence of RIR. Hence, the use of antioxidant compounds can improve oxidative stress due to RIR. This review highlights herbal antioxidant efficacy against RIR injury. The findings of this study indicate that antioxidant compounds with herbal origin could reduce complications due to oxidative stress related to RIR through diminishing lipid peroxidation, decreased production of malondialdehyde (MDA), apoptosis and increasing antioxidant enzymes activity. Reducing oxidative stress with the pharmacological approach of antioxidants can be a desirable target for ameliorating RIR.
format	article
author	Masoumeh Asgharpour Audrey Tolouian Lakkakula VKS Bhaskar Ramin Tolouian Nilofar Massoudi
author_facet	Masoumeh Asgharpour Audrey Tolouian Lakkakula VKS Bhaskar Ramin Tolouian Nilofar Massoudi
author_sort	Masoumeh Asgharpour
title	Herbal antioxidants and renal ischemic-reperfusion injury; an updated review
title_short	Herbal antioxidants and renal ischemic-reperfusion injury; an updated review
title_full	Herbal antioxidants and renal ischemic-reperfusion injury; an updated review
title_fullStr	Herbal antioxidants and renal ischemic-reperfusion injury; an updated review
title_full_unstemmed	Herbal antioxidants and renal ischemic-reperfusion injury; an updated review
title_sort	herbal antioxidants and renal ischemic-reperfusion injury; an updated review
publisher	Society of Diabetic Nephropathy Prevention
publishDate	2021
url	https://doaj.org/article/fe49295c18ce45479ed797075926d4c2
work_keys_str_mv	AT masoumehasgharpour herbalantioxidantsandrenalischemicreperfusioninjuryanupdatedreview AT audreytolouian herbalantioxidantsandrenalischemicreperfusioninjuryanupdatedreview AT lakkakulavksbhaskar herbalantioxidantsandrenalischemicreperfusioninjuryanupdatedreview AT ramintolouian herbalantioxidantsandrenalischemicreperfusioninjuryanupdatedreview AT nilofarmassoudi herbalantioxidantsandrenalischemicreperfusioninjuryanupdatedreview
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Herbal antioxidants and renal ischemic-reperfusion injury; an updated review

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