Portable rotating grating stimulation for anisometropic amblyopia with 6 months training

Abstract Treatment of grating stimulation has been used in amblyopia for decades, but high dropout rate and inconvenience for daily practice occur in previous studies. We developed a home-based portable system with rotating grating stimulation on a tablet. Thirty anisometropic amblyopic children wer...

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Autores principales:	Wen-Hsiu Yeh, Li-Ju Lai, Da-Wei Chang, Wei-Sin Lin, Guan-Ming Lin, Fu-Zen Shaw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe4946b6fd6c49d9afc5cbbbfbb87fc4
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spelling	oai:doaj.org-article:fe4946b6fd6c49d9afc5cbbbfbb87fc42021-12-02T17:50:41ZPortable rotating grating stimulation for anisometropic amblyopia with 6 months training10.1038/s41598-021-90936-72045-2322https://doaj.org/article/fe4946b6fd6c49d9afc5cbbbfbb87fc42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90936-7https://doaj.org/toc/2045-2322Abstract Treatment of grating stimulation has been used in amblyopia for decades, but high dropout rate and inconvenience for daily practice occur in previous studies. We developed a home-based portable system with rotating grating stimulation on a tablet. Thirty anisometropic amblyopic children were randomly allocated into the control or Grating group. They drew contour of the picture under patch of a better eye for 6 months. Best-corrected visual acuity (BCVA), grating acuity (GA), and contrast sensitivity (CS) were assessed at the baseline, 1st, 2nd, 3rd, and 6th months of training. All participants completed the 6-month training. Patched eyes of both groups exhibited no difference. Trained eyes of the control group had significantly slight improvement in BCVA and GA. In particular, the Grating group exhibited significantly higher BCVA, GA, and CS compared with those of the control group at the 3rd and 6th months of training. Moreover, percentage of the Grating group with great improvement (BCVA ≥ 0.3 or CS ≥ 0.3) was significantly larger than those of the control group at the 3rd or 6th months of training. The portable grating stimulation system demonstrates its trainability by no dropout and effectiveness by significant improvements in all assessments through a well experimental design. Trial Registration: ClinicalTrials.gov NCT04213066, registered 30/12/2019, https://clinicaltrials.gov/ct2/show/NCT04213066 .Wen-Hsiu YehLi-Ju LaiDa-Wei ChangWei-Sin LinGuan-Ming LinFu-Zen ShawNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wen-Hsiu Yeh Li-Ju Lai Da-Wei Chang Wei-Sin Lin Guan-Ming Lin Fu-Zen Shaw Portable rotating grating stimulation for anisometropic amblyopia with 6 months training
description	Abstract Treatment of grating stimulation has been used in amblyopia for decades, but high dropout rate and inconvenience for daily practice occur in previous studies. We developed a home-based portable system with rotating grating stimulation on a tablet. Thirty anisometropic amblyopic children were randomly allocated into the control or Grating group. They drew contour of the picture under patch of a better eye for 6 months. Best-corrected visual acuity (BCVA), grating acuity (GA), and contrast sensitivity (CS) were assessed at the baseline, 1st, 2nd, 3rd, and 6th months of training. All participants completed the 6-month training. Patched eyes of both groups exhibited no difference. Trained eyes of the control group had significantly slight improvement in BCVA and GA. In particular, the Grating group exhibited significantly higher BCVA, GA, and CS compared with those of the control group at the 3rd and 6th months of training. Moreover, percentage of the Grating group with great improvement (BCVA ≥ 0.3 or CS ≥ 0.3) was significantly larger than those of the control group at the 3rd or 6th months of training. The portable grating stimulation system demonstrates its trainability by no dropout and effectiveness by significant improvements in all assessments through a well experimental design. Trial Registration: ClinicalTrials.gov NCT04213066, registered 30/12/2019, https://clinicaltrials.gov/ct2/show/NCT04213066 .
format	article
author	Wen-Hsiu Yeh Li-Ju Lai Da-Wei Chang Wei-Sin Lin Guan-Ming Lin Fu-Zen Shaw
author_facet	Wen-Hsiu Yeh Li-Ju Lai Da-Wei Chang Wei-Sin Lin Guan-Ming Lin Fu-Zen Shaw
author_sort	Wen-Hsiu Yeh
title	Portable rotating grating stimulation for anisometropic amblyopia with 6 months training
title_short	Portable rotating grating stimulation for anisometropic amblyopia with 6 months training
title_full	Portable rotating grating stimulation for anisometropic amblyopia with 6 months training
title_fullStr	Portable rotating grating stimulation for anisometropic amblyopia with 6 months training
title_full_unstemmed	Portable rotating grating stimulation for anisometropic amblyopia with 6 months training
title_sort	portable rotating grating stimulation for anisometropic amblyopia with 6 months training
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe4946b6fd6c49d9afc5cbbbfbb87fc4
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Portable rotating grating stimulation for anisometropic amblyopia with 6 months training

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