Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling in...

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Autores principales:	Jayaram Vijayakrishnan, Maoxiang Qian, James B. Studd, Wenjian Yang, Ben Kinnersley, Philip J. Law, Peter Broderick, Elizabeth A. Raetz, James Allan, Ching-Hon Pui, Ajay Vora, William E. Evans, Anthony Moorman, Allen Yeoh, Wentao Yang, Chunliang Li, Claus R. Bartram, Charles G. Mullighan, Martin Zimmerman, Stephen P. Hunger, Martin Schrappe, Mary V. Relling, Martin Stanulla, Mignon L. Loh, Richard S. Houlston, Jun J. Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe499f58e3cb45709aa02c81074cf619
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spelling	oai:doaj.org-article:fe499f58e3cb45709aa02c81074cf6192021-12-02T17:01:59ZIdentification of four novel associations for B-cell acute lymphoblastic leukaemia risk10.1038/s41467-019-13069-62041-1723https://doaj.org/article/fe499f58e3cb45709aa02c81074cf6192019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13069-6https://doaj.org/toc/2041-1723B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.Jayaram VijayakrishnanMaoxiang QianJames B. StuddWenjian YangBen KinnersleyPhilip J. LawPeter BroderickElizabeth A. RaetzJames AllanChing-Hon PuiAjay VoraWilliam E. EvansAnthony MoormanAllen YeohWentao YangChunliang LiClaus R. BartramCharles G. MullighanMartin ZimmermanStephen P. HungerMartin SchrappeMary V. RellingMartin StanullaMignon L. LohRichard S. HoulstonJun J. YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jayaram Vijayakrishnan Maoxiang Qian James B. Studd Wenjian Yang Ben Kinnersley Philip J. Law Peter Broderick Elizabeth A. Raetz James Allan Ching-Hon Pui Ajay Vora William E. Evans Anthony Moorman Allen Yeoh Wentao Yang Chunliang Li Claus R. Bartram Charles G. Mullighan Martin Zimmerman Stephen P. Hunger Martin Schrappe Mary V. Relling Martin Stanulla Mignon L. Loh Richard S. Houlston Jun J. Yang Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
description	B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.
format	article
author	Jayaram Vijayakrishnan Maoxiang Qian James B. Studd Wenjian Yang Ben Kinnersley Philip J. Law Peter Broderick Elizabeth A. Raetz James Allan Ching-Hon Pui Ajay Vora William E. Evans Anthony Moorman Allen Yeoh Wentao Yang Chunliang Li Claus R. Bartram Charles G. Mullighan Martin Zimmerman Stephen P. Hunger Martin Schrappe Mary V. Relling Martin Stanulla Mignon L. Loh Richard S. Houlston Jun J. Yang
author_facet	Jayaram Vijayakrishnan Maoxiang Qian James B. Studd Wenjian Yang Ben Kinnersley Philip J. Law Peter Broderick Elizabeth A. Raetz James Allan Ching-Hon Pui Ajay Vora William E. Evans Anthony Moorman Allen Yeoh Wentao Yang Chunliang Li Claus R. Bartram Charles G. Mullighan Martin Zimmerman Stephen P. Hunger Martin Schrappe Mary V. Relling Martin Stanulla Mignon L. Loh Richard S. Houlston Jun J. Yang
author_sort	Jayaram Vijayakrishnan
title	Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
title_short	Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
title_full	Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
title_fullStr	Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
title_full_unstemmed	Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
title_sort	identification of four novel associations for b-cell acute lymphoblastic leukaemia risk
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fe499f58e3cb45709aa02c81074cf619
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Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

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