Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory...

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Auteurs principaux:	Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J. Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G. Lechner, Paul A. Heppenstall
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fe4dc2a3ccaf4f5496713ff8538a5861
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spelling	oai:doaj.org-article:fe4dc2a3ccaf4f5496713ff8538a58612021-12-02T16:56:37ZControl of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons10.1038/s41467-018-04049-32041-1723https://doaj.org/article/fe4dc2a3ccaf4f5496713ff8538a58612018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04049-3https://doaj.org/toc/2041-1723There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory neurons in the mouse skin attenuates this hypersensitivity.Rahul DhandapaniCynthia Mary ArokiarajFrancisco J. TabernerPaola PacificoSruthi RajaLinda NocchiCarla PortulanoFederica FranciosaMariano MaffeiAhmad Fawzi HussainFernanda de Castro ReisLuc ReymondEmerald PerlasSimone GarcovichStefan BarthKai JohnssonStefan G. LechnerPaul A. HeppenstallNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rahul Dhandapani Cynthia Mary Arokiaraj Francisco J. Taberner Paola Pacifico Sruthi Raja Linda Nocchi Carla Portulano Federica Franciosa Mariano Maffei Ahmad Fawzi Hussain Fernanda de Castro Reis Luc Reymond Emerald Perlas Simone Garcovich Stefan Barth Kai Johnsson Stefan G. Lechner Paul A. Heppenstall Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
description	There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory neurons in the mouse skin attenuates this hypersensitivity.
format	article
author	Rahul Dhandapani Cynthia Mary Arokiaraj Francisco J. Taberner Paola Pacifico Sruthi Raja Linda Nocchi Carla Portulano Federica Franciosa Mariano Maffei Ahmad Fawzi Hussain Fernanda de Castro Reis Luc Reymond Emerald Perlas Simone Garcovich Stefan Barth Kai Johnsson Stefan G. Lechner Paul A. Heppenstall
author_facet	Rahul Dhandapani Cynthia Mary Arokiaraj Francisco J. Taberner Paola Pacifico Sruthi Raja Linda Nocchi Carla Portulano Federica Franciosa Mariano Maffei Ahmad Fawzi Hussain Fernanda de Castro Reis Luc Reymond Emerald Perlas Simone Garcovich Stefan Barth Kai Johnsson Stefan G. Lechner Paul A. Heppenstall
author_sort	Rahul Dhandapani
title	Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
title_short	Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
title_full	Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
title_fullStr	Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
title_full_unstemmed	Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
title_sort	control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of trkb-positive sensory neurons
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe4dc2a3ccaf4f5496713ff8538a5861
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Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

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