Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

The use of tumour exosome-activated dendritic cell (DC) immunotherapy shows promise for the treatment of large established tumours. Here, the authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting DC activation in several preclinical mouse mo...

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Autores principales: Bingfeng Zuo, Han Qi, Zhen Lu, Lu Chen, Bo Sun, Rong Yang, Yang Zhang, Zhili Liu, Xianjun Gao, Abin You, Li Wu, Renwei Jing, Qibing Zhou, HaiFang Yin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/fe4fbc85947e42be8068f1782617b5b6
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spelling oai:doaj.org-article:fe4fbc85947e42be8068f1782617b5b62021-12-02T17:32:11ZAlarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice10.1038/s41467-020-15569-22041-1723https://doaj.org/article/fe4fbc85947e42be8068f1782617b5b62020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15569-2https://doaj.org/toc/2041-1723The use of tumour exosome-activated dendritic cell (DC) immunotherapy shows promise for the treatment of large established tumours. Here, the authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting DC activation in several preclinical mouse models.Bingfeng ZuoHan QiZhen LuLu ChenBo SunRong YangYang ZhangZhili LiuXianjun GaoAbin YouLi WuRenwei JingQibing ZhouHaiFang YinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bingfeng Zuo
Han Qi
Zhen Lu
Lu Chen
Bo Sun
Rong Yang
Yang Zhang
Zhili Liu
Xianjun Gao
Abin You
Li Wu
Renwei Jing
Qibing Zhou
HaiFang Yin
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
description The use of tumour exosome-activated dendritic cell (DC) immunotherapy shows promise for the treatment of large established tumours. Here, the authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting DC activation in several preclinical mouse models.
format article
author Bingfeng Zuo
Han Qi
Zhen Lu
Lu Chen
Bo Sun
Rong Yang
Yang Zhang
Zhili Liu
Xianjun Gao
Abin You
Li Wu
Renwei Jing
Qibing Zhou
HaiFang Yin
author_facet Bingfeng Zuo
Han Qi
Zhen Lu
Lu Chen
Bo Sun
Rong Yang
Yang Zhang
Zhili Liu
Xianjun Gao
Abin You
Li Wu
Renwei Jing
Qibing Zhou
HaiFang Yin
author_sort Bingfeng Zuo
title Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
title_short Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
title_full Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
title_fullStr Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
title_full_unstemmed Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
title_sort alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/fe4fbc85947e42be8068f1782617b5b6
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