Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models...
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Nature Portfolio
2019
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oai:doaj.org-article:fe549d39d8134e549baba3508cc6c30c2021-12-02T16:57:54ZEnantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters10.1038/s41467-019-12702-82041-1723https://doaj.org/article/fe549d39d8134e549baba3508cc6c30c2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12702-8https://doaj.org/toc/2041-1723The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.Kaixi ZhangYu DuZhangyong SiYang LiuMichelle E. TurveyCheerlavancha RajuDamien KeoghLin RuanSubramanion L. JothySheethal ReghuKalisvar MarimuthuPartha Pratim DeOon Tek NgJosé R. MediavillaBarry N. KreiswirthYonggui Robin ChiJinghua RenKam C. TamXue-Wei LiuHongwei DuanYabin ZhuYuguang MuPaula T. HammondGuillermo C. BazanKevin PetheMary B. Chan-ParkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
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| collection |
DOAJ |
| language |
EN |
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Science Q |
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Science Q Kaixi Zhang Yu Du Zhangyong Si Yang Liu Michelle E. Turvey Cheerlavancha Raju Damien Keogh Lin Ruan Subramanion L. Jothy Sheethal Reghu Kalisvar Marimuthu Partha Pratim De Oon Tek Ng José R. Mediavilla Barry N. Kreiswirth Yonggui Robin Chi Jinghua Ren Kam C. Tam Xue-Wei Liu Hongwei Duan Yabin Zhu Yuguang Mu Paula T. Hammond Guillermo C. Bazan Kevin Pethe Mary B. Chan-Park Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| description |
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity. |
| format |
article |
| author |
Kaixi Zhang Yu Du Zhangyong Si Yang Liu Michelle E. Turvey Cheerlavancha Raju Damien Keogh Lin Ruan Subramanion L. Jothy Sheethal Reghu Kalisvar Marimuthu Partha Pratim De Oon Tek Ng José R. Mediavilla Barry N. Kreiswirth Yonggui Robin Chi Jinghua Ren Kam C. Tam Xue-Wei Liu Hongwei Duan Yabin Zhu Yuguang Mu Paula T. Hammond Guillermo C. Bazan Kevin Pethe Mary B. Chan-Park |
| author_facet |
Kaixi Zhang Yu Du Zhangyong Si Yang Liu Michelle E. Turvey Cheerlavancha Raju Damien Keogh Lin Ruan Subramanion L. Jothy Sheethal Reghu Kalisvar Marimuthu Partha Pratim De Oon Tek Ng José R. Mediavilla Barry N. Kreiswirth Yonggui Robin Chi Jinghua Ren Kam C. Tam Xue-Wei Liu Hongwei Duan Yabin Zhu Yuguang Mu Paula T. Hammond Guillermo C. Bazan Kevin Pethe Mary B. Chan-Park |
| author_sort |
Kaixi Zhang |
| title |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_short |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_full |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_fullStr |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_full_unstemmed |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_sort |
enantiomeric glycosylated cationic block co-beta-peptides eradicate staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/fe549d39d8134e549baba3508cc6c30c |
| work_keys_str_mv |
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