Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer

Circulating tumor DNA (ctDNA) may provide a prediction of treatment response, but could be impacted by tumor heterogeneity. Here, the authors investigate ctDNA in CDK4/6 inhibitor treatment in advanced breast cancer, finding ctDNA levels predict progression-free survival and anticipate clonal select...

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Autores principales:	Ben O’Leary, Sarah Hrebien, James P. Morden, Matthew Beaney, Charlotte Fribbens, Xin Huang, Yuan Liu, Cynthia Huang Bartlett, Maria Koehler, Massimo Cristofanilli, Isaac Garcia-Murillas, Judith M. Bliss, Nicholas C. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe55104b6a3946c08222bef99156c284
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spelling	oai:doaj.org-article:fe55104b6a3946c08222bef99156c2842021-12-02T17:32:44ZEarly circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer10.1038/s41467-018-03215-x2041-1723https://doaj.org/article/fe55104b6a3946c08222bef99156c2842018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03215-xhttps://doaj.org/toc/2041-1723Circulating tumor DNA (ctDNA) may provide a prediction of treatment response, but could be impacted by tumor heterogeneity. Here, the authors investigate ctDNA in CDK4/6 inhibitor treatment in advanced breast cancer, finding ctDNA levels predict progression-free survival and anticipate clonal selection.Ben O’LearySarah HrebienJames P. MordenMatthew BeaneyCharlotte FribbensXin HuangYuan LiuCynthia Huang BartlettMaria KoehlerMassimo CristofanilliIsaac Garcia-MurillasJudith M. BlissNicholas C. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ben O’Leary Sarah Hrebien James P. Morden Matthew Beaney Charlotte Fribbens Xin Huang Yuan Liu Cynthia Huang Bartlett Maria Koehler Massimo Cristofanilli Isaac Garcia-Murillas Judith M. Bliss Nicholas C. Turner Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
description	Circulating tumor DNA (ctDNA) may provide a prediction of treatment response, but could be impacted by tumor heterogeneity. Here, the authors investigate ctDNA in CDK4/6 inhibitor treatment in advanced breast cancer, finding ctDNA levels predict progression-free survival and anticipate clonal selection.
format	article
author	Ben O’Leary Sarah Hrebien James P. Morden Matthew Beaney Charlotte Fribbens Xin Huang Yuan Liu Cynthia Huang Bartlett Maria Koehler Massimo Cristofanilli Isaac Garcia-Murillas Judith M. Bliss Nicholas C. Turner
author_facet	Ben O’Leary Sarah Hrebien James P. Morden Matthew Beaney Charlotte Fribbens Xin Huang Yuan Liu Cynthia Huang Bartlett Maria Koehler Massimo Cristofanilli Isaac Garcia-Murillas Judith M. Bliss Nicholas C. Turner
author_sort	Ben O’Leary
title	Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
title_short	Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
title_full	Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
title_fullStr	Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
title_full_unstemmed	Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
title_sort	early circulating tumor dna dynamics and clonal selection with palbociclib and fulvestrant for breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe55104b6a3946c08222bef99156c284
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Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer

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