Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.

<h4>Background</h4>We developed a jejunal and colonic experimental human ischemia-reperfusion (IR) model to study pathophysiological intestinal IR mechanisms and potential new intestinal ischemia biomarkers. Our objective was to evaluate the safety of these IR models by comparing patient...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Inca H R Hundscheid, Dirk H S M Schellekens, Joep Grootjans, Marcel Den Dulk, Ronald M Van Dam, Geerard L Beets, Wim A Buurman, Kaatje Lenaerts, Joep P M Derikx, Cornelis H C Dejong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe55f9ae98a648f184efc56f55753e21
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fe55f9ae98a648f184efc56f55753e21
record_format	dspace
spelling	oai:doaj.org-article:fe55f9ae98a648f184efc56f55753e212021-12-02T20:10:21ZEvaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.1932-620310.1371/journal.pone.0253506https://doaj.org/article/fe55f9ae98a648f184efc56f55753e212021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253506https://doaj.org/toc/1932-6203<h4>Background</h4>We developed a jejunal and colonic experimental human ischemia-reperfusion (IR) model to study pathophysiological intestinal IR mechanisms and potential new intestinal ischemia biomarkers. Our objective was to evaluate the safety of these IR models by comparing patients undergoing surgery with and without in vivo intestinal IR.<h4>Methods</h4>A retrospective study was performed comparing complication rates and severity, based on the Clavien-Dindo classification system, in patients undergoing pancreatoduodenectomy with (n = 10) and without (n = 20 matched controls) jejunal IR or colorectal surgery with (n = 10) and without (n = 20 matched controls) colon IR. Secondary outcome parameters were operative time, blood loss, 90-day mortality and length of hospital stay.<h4>Results</h4>Following pancreatic surgery, 63% of the patients experienced one or more postoperative complications. There was no significant difference in incidence or severity of complications between patients undergoing pancreatic surgery with (70%) or without (60%, P = 0.7) jejunal IR. Following colorectal surgery, 60% of the patients experienced one or more postoperative complication. Complication rate and severity were similar in patients with (50%) and without (65%, P = 0.46) colonic IR. Operative time, amount of blood loss, postoperative C-reactive protein, length of hospital stay or mortality were equal in both intervention and control groups for jejunal and colon IR.<h4>Conclusion</h4>This study showed that human experimental intestinal IR models are safe in patients undergoing pancreatic or colorectal surgery.Inca H R HundscheidDirk H S M SchellekensJoep GrootjansMarcel Den DulkRonald M Van DamGeerard L BeetsWim A BuurmanKaatje LenaertsJoep P M DerikxCornelis H C DejongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253506 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Inca H R Hundscheid Dirk H S M Schellekens Joep Grootjans Marcel Den Dulk Ronald M Van Dam Geerard L Beets Wim A Buurman Kaatje Lenaerts Joep P M Derikx Cornelis H C Dejong Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.
description	<h4>Background</h4>We developed a jejunal and colonic experimental human ischemia-reperfusion (IR) model to study pathophysiological intestinal IR mechanisms and potential new intestinal ischemia biomarkers. Our objective was to evaluate the safety of these IR models by comparing patients undergoing surgery with and without in vivo intestinal IR.<h4>Methods</h4>A retrospective study was performed comparing complication rates and severity, based on the Clavien-Dindo classification system, in patients undergoing pancreatoduodenectomy with (n = 10) and without (n = 20 matched controls) jejunal IR or colorectal surgery with (n = 10) and without (n = 20 matched controls) colon IR. Secondary outcome parameters were operative time, blood loss, 90-day mortality and length of hospital stay.<h4>Results</h4>Following pancreatic surgery, 63% of the patients experienced one or more postoperative complications. There was no significant difference in incidence or severity of complications between patients undergoing pancreatic surgery with (70%) or without (60%, P = 0.7) jejunal IR. Following colorectal surgery, 60% of the patients experienced one or more postoperative complication. Complication rate and severity were similar in patients with (50%) and without (65%, P = 0.46) colonic IR. Operative time, amount of blood loss, postoperative C-reactive protein, length of hospital stay or mortality were equal in both intervention and control groups for jejunal and colon IR.<h4>Conclusion</h4>This study showed that human experimental intestinal IR models are safe in patients undergoing pancreatic or colorectal surgery.
format	article
author	Inca H R Hundscheid Dirk H S M Schellekens Joep Grootjans Marcel Den Dulk Ronald M Van Dam Geerard L Beets Wim A Buurman Kaatje Lenaerts Joep P M Derikx Cornelis H C Dejong
author_facet	Inca H R Hundscheid Dirk H S M Schellekens Joep Grootjans Marcel Den Dulk Ronald M Van Dam Geerard L Beets Wim A Buurman Kaatje Lenaerts Joep P M Derikx Cornelis H C Dejong
author_sort	Inca H R Hundscheid
title	Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.
title_short	Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.
title_full	Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.
title_fullStr	Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.
title_full_unstemmed	Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.
title_sort	evaluating the safety of two human experimental intestinal ischemia reperfusion models: a retrospective observational study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fe55f9ae98a648f184efc56f55753e21
work_keys_str_mv	AT incahrhundscheid evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT dirkhsmschellekens evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT joepgrootjans evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT marceldendulk evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT ronaldmvandam evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT geerardlbeets evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT wimabuurman evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT kaatjelenaerts evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT joeppmderikx evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy AT cornelishcdejong evaluatingthesafetyoftwohumanexperimentalintestinalischemiareperfusionmodelsaretrospectiveobservationalstudy
_version_	1718375040338100224

Evaluating the safety of two human experimental intestinal ischemia reperfusion models: A retrospective observational study.

Ejemplares similares