Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote funct...

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Autores principales:	Atefeh Zarepour, Sara Hooshmand, Aylin Gökmen, Ali Zarrabi, Ebrahim Mostafavi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spinal cord injury stem cells 3D bioprinting tissue regeneration neural tissue engineering Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fe59a2505b2a4984a0c4bfa989b4544c
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spelling	oai:doaj.org-article:fe59a2505b2a4984a0c4bfa989b4544c2021-11-25T17:12:38ZSpinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms10.3390/cells101131892073-4409https://doaj.org/article/fe59a2505b2a4984a0c4bfa989b4544c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3189https://doaj.org/toc/2073-4409Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI.Atefeh ZarepourSara HooshmandAylin GökmenAli ZarrabiEbrahim MostafaviMDPI AGarticlespinal cord injurystem cells3D bioprintingtissue regenerationneural tissue engineeringBiology (General)QH301-705.5ENCells, Vol 10, Iss 3189, p 3189 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury stem cells 3D bioprinting tissue regeneration neural tissue engineering Biology (General) QH301-705.5
spellingShingle	spinal cord injury stem cells 3D bioprinting tissue regeneration neural tissue engineering Biology (General) QH301-705.5 Atefeh Zarepour Sara Hooshmand Aylin Gökmen Ali Zarrabi Ebrahim Mostafavi Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
description	Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI.
format	article
author	Atefeh Zarepour Sara Hooshmand Aylin Gökmen Ali Zarrabi Ebrahim Mostafavi
author_facet	Atefeh Zarepour Sara Hooshmand Aylin Gökmen Ali Zarrabi Ebrahim Mostafavi
author_sort	Atefeh Zarepour
title	Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
title_short	Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
title_full	Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
title_fullStr	Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
title_full_unstemmed	Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
title_sort	spinal cord injury management through the combination of stem cells and implantable 3d bioprinted platforms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fe59a2505b2a4984a0c4bfa989b4544c
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Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

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