Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia
The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the demethylating compound 5′-Azacitdine increases anti-CD123 CAR-T cell cytotoxicity against AML.
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Nature Portfolio
2021
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oai:doaj.org-article:fe5a9441efac4b52a10770a66f35954d2021-11-14T12:36:27ZDemethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia10.1038/s41467-021-26683-02041-1723https://doaj.org/article/fe5a9441efac4b52a10770a66f35954d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26683-0https://doaj.org/toc/2041-1723The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the demethylating compound 5′-Azacitdine increases anti-CD123 CAR-T cell cytotoxicity against AML.Nadia El KhawankyAmy HughesWenbo YuRenier MyburghTony MatschullaSanaz TaromiKonrad AumannJade ClarsonJanaki Manoja VinnakotaKhalid ShoumariyehCornelius MiethingAngel F. LopezMichael P. BrownJustus DuysterLutz HeinMarkus G. ManzTimothy P. HughesDeborah L. WhiteAgnes S. M. YongRobert ZeiserNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nadia El Khawanky Amy Hughes Wenbo Yu Renier Myburgh Tony Matschulla Sanaz Taromi Konrad Aumann Jade Clarson Janaki Manoja Vinnakota Khalid Shoumariyeh Cornelius Miething Angel F. Lopez Michael P. Brown Justus Duyster Lutz Hein Markus G. Manz Timothy P. Hughes Deborah L. White Agnes S. M. Yong Robert Zeiser Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia |
| description |
The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the demethylating compound 5′-Azacitdine increases anti-CD123 CAR-T cell cytotoxicity against AML. |
| format |
article |
| author |
Nadia El Khawanky Amy Hughes Wenbo Yu Renier Myburgh Tony Matschulla Sanaz Taromi Konrad Aumann Jade Clarson Janaki Manoja Vinnakota Khalid Shoumariyeh Cornelius Miething Angel F. Lopez Michael P. Brown Justus Duyster Lutz Hein Markus G. Manz Timothy P. Hughes Deborah L. White Agnes S. M. Yong Robert Zeiser |
| author_facet |
Nadia El Khawanky Amy Hughes Wenbo Yu Renier Myburgh Tony Matschulla Sanaz Taromi Konrad Aumann Jade Clarson Janaki Manoja Vinnakota Khalid Shoumariyeh Cornelius Miething Angel F. Lopez Michael P. Brown Justus Duyster Lutz Hein Markus G. Manz Timothy P. Hughes Deborah L. White Agnes S. M. Yong Robert Zeiser |
| author_sort |
Nadia El Khawanky |
| title |
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia |
| title_short |
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia |
| title_full |
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia |
| title_fullStr |
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia |
| title_full_unstemmed |
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia |
| title_sort |
demethylating therapy increases anti-cd123 car t cell cytotoxicity against acute myeloid leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fe5a9441efac4b52a10770a66f35954d |
| work_keys_str_mv |
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1718429145727238144 |