The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

ADP-ribosylation is regulated by HPF1 and ARH3, but the cellular target spectrum of these enzymes is not fully understood. Here, the authors use quantitative proteomics to define the HPF1- and ARH3-dependent ADP-ribosylome, providing evidence that mono-ADP-ribosylation of serine predominates in cell...

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Autores principales:	Ivo A. Hendriks, Sara C. Buch-Larsen, Evgeniia Prokhorova, Jonas D. Elsborg, Alexandra K.L.F.S. Rebak, Kang Zhu, Dragana Ahel, Claudia Lukas, Ivan Ahel, Michael L. Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe5e0ce471514232be42e096a42ca2cd
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spelling	oai:doaj.org-article:fe5e0ce471514232be42e096a42ca2cd2021-12-02T18:37:17ZThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome10.1038/s41467-021-26172-42041-1723https://doaj.org/article/fe5e0ce471514232be42e096a42ca2cd2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26172-4https://doaj.org/toc/2041-1723ADP-ribosylation is regulated by HPF1 and ARH3, but the cellular target spectrum of these enzymes is not fully understood. Here, the authors use quantitative proteomics to define the HPF1- and ARH3-dependent ADP-ribosylome, providing evidence that mono-ADP-ribosylation of serine predominates in cells.Ivo A. HendriksSara C. Buch-LarsenEvgeniia ProkhorovaJonas D. ElsborgAlexandra K.L.F.S. RebakKang ZhuDragana AhelClaudia LukasIvan AhelMichael L. NielsenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivo A. Hendriks Sara C. Buch-Larsen Evgeniia Prokhorova Jonas D. Elsborg Alexandra K.L.F.S. Rebak Kang Zhu Dragana Ahel Claudia Lukas Ivan Ahel Michael L. Nielsen The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
description	ADP-ribosylation is regulated by HPF1 and ARH3, but the cellular target spectrum of these enzymes is not fully understood. Here, the authors use quantitative proteomics to define the HPF1- and ARH3-dependent ADP-ribosylome, providing evidence that mono-ADP-ribosylation of serine predominates in cells.
format	article
author	Ivo A. Hendriks Sara C. Buch-Larsen Evgeniia Prokhorova Jonas D. Elsborg Alexandra K.L.F.S. Rebak Kang Zhu Dragana Ahel Claudia Lukas Ivan Ahel Michael L. Nielsen
author_facet	Ivo A. Hendriks Sara C. Buch-Larsen Evgeniia Prokhorova Jonas D. Elsborg Alexandra K.L.F.S. Rebak Kang Zhu Dragana Ahel Claudia Lukas Ivan Ahel Michael L. Nielsen
author_sort	Ivo A. Hendriks
title	The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
title_short	The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
title_full	The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
title_fullStr	The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
title_full_unstemmed	The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
title_sort	regulatory landscape of the human hpf1- and arh3-dependent adp-ribosylome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe5e0ce471514232be42e096a42ca2cd
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The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

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