Infectious bursal disease virus in poultry: current status and future prospects

Tamiru Negash Alkie,1 Silke Rautenschlein21Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada; 2Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, GermanyAbstract: Infectious bursal disease virus (IBDV) affects immature B lymphocytes o...

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Autores principales:	Alkie TN, Rautenschlein S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Epidemiology IBDV immunity poultry vaccine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fe62e8ecd4e54503bdecfe372173acbf
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spelling	oai:doaj.org-article:fe62e8ecd4e54503bdecfe372173acbf2021-12-02T02:03:06ZInfectious bursal disease virus in poultry: current status and future prospects2230-2034https://doaj.org/article/fe62e8ecd4e54503bdecfe372173acbf2016-01-01T00:00:00Zhttps://www.dovepress.com/infectious-bursal-disease-virus-in-poultry-current-status-and-future-p-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Tamiru Negash Alkie,1 Silke Rautenschlein21Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada; 2Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, GermanyAbstract: Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.Keywords: epidemiology, IBDV, immunity, poultry, vaccineAlkie TNRautenschlein SDove Medical PressarticleEpidemiologyIBDVimmunitypoultryvaccineVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2016, Iss Issue 1, Pp 9-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epidemiology IBDV immunity poultry vaccine Veterinary medicine SF600-1100
spellingShingle	Epidemiology IBDV immunity poultry vaccine Veterinary medicine SF600-1100 Alkie TN Rautenschlein S Infectious bursal disease virus in poultry: current status and future prospects
description	Tamiru Negash Alkie,1 Silke Rautenschlein21Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada; 2Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, GermanyAbstract: Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.Keywords: epidemiology, IBDV, immunity, poultry, vaccine
format	article
author	Alkie TN Rautenschlein S
author_facet	Alkie TN Rautenschlein S
author_sort	Alkie TN
title	Infectious bursal disease virus in poultry: current status and future prospects
title_short	Infectious bursal disease virus in poultry: current status and future prospects
title_full	Infectious bursal disease virus in poultry: current status and future prospects
title_fullStr	Infectious bursal disease virus in poultry: current status and future prospects
title_full_unstemmed	Infectious bursal disease virus in poultry: current status and future prospects
title_sort	infectious bursal disease virus in poultry: current status and future prospects
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/fe62e8ecd4e54503bdecfe372173acbf
work_keys_str_mv	AT alkietn infectiousbursaldiseasevirusinpoultrycurrentstatusandfutureprospects AT rautenschleins infectiousbursaldiseasevirusinpoultrycurrentstatusandfutureprospects
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Infectious bursal disease virus in poultry: current status and future prospects

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