Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk
Abstract Venous thromboembolism is associated with formation of denser fibrin clots resistant to lysis. We investigated whether prothrombotic plasma clot properties are associated with the severity of acute pulmonary embolism (PE). We enrolled 126 normotensive acute PE patients (aged 58 ± 14 years)...
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Nature Portfolio
2020
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oai:doaj.org-article:fe63441b4ca843fdbf160c8b3a01c3482021-12-02T15:39:39ZProthrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk10.1038/s41598-020-68375-72045-2322https://doaj.org/article/fe63441b4ca843fdbf160c8b3a01c3482020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68375-7https://doaj.org/toc/2045-2322Abstract Venous thromboembolism is associated with formation of denser fibrin clots resistant to lysis. We investigated whether prothrombotic plasma clot properties are associated with the severity of acute pulmonary embolism (PE). We enrolled 126 normotensive acute PE patients (aged 58 ± 14 years) and 25 age- and sex-matched healthy controls. Plasma fibrin clot permeability (Ks), clot lysis time (CLT), endogenous thrombin potential (ETP), plasminogen activator inhibitor-1 (PAI-1), and citrullinated histone H3 (citH3) were evaluated on admission. PE patients compared to controls had 370% higher citH3 levels, 41% higher ETP, 16.5% reduced Ks, and 25.6% prolonged CLT. Patients with intermediate-high (n = 29) and intermediate-low (n = 77) PE mortality risk had reduced Ks and prolonged CLT, increased PAI-1 and ETP as compared to low-risk PE (n = 20) patients. Prolonged CLT was predicted by PAI-1 and citH3, while low Ks by C-reactive protein. During a 12-month follow-up 9 (7.1%) patients who had 24% higher ETP, 45% higher citH3 levels, and 18% prolonged CLT at baseline died. High ETP combined with elevated citH3 levels and prolonged CLT was associated with eightfold increased risk of PE-related death. Prothrombotic fibrin clot properties and enhanced neutrophil extracellular traps formation are associated with higher early mortality risk in acute PE patients, which suggests a prognostic role of these biomarkers.Michał ZąbczykJoanna NatorskaAgnieszka Janion-SadowskaAgnieszka Metzgier-GumielaMateusz PolakKrzysztof PlensMarianna JanionGrzegorz SkoniecznyKatarzyna Mizia-StecAnetta UndasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
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Medicine R Science Q Michał Ząbczyk Joanna Natorska Agnieszka Janion-Sadowska Agnieszka Metzgier-Gumiela Mateusz Polak Krzysztof Plens Marianna Janion Grzegorz Skonieczny Katarzyna Mizia-Stec Anetta Undas Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk |
| description |
Abstract Venous thromboembolism is associated with formation of denser fibrin clots resistant to lysis. We investigated whether prothrombotic plasma clot properties are associated with the severity of acute pulmonary embolism (PE). We enrolled 126 normotensive acute PE patients (aged 58 ± 14 years) and 25 age- and sex-matched healthy controls. Plasma fibrin clot permeability (Ks), clot lysis time (CLT), endogenous thrombin potential (ETP), plasminogen activator inhibitor-1 (PAI-1), and citrullinated histone H3 (citH3) were evaluated on admission. PE patients compared to controls had 370% higher citH3 levels, 41% higher ETP, 16.5% reduced Ks, and 25.6% prolonged CLT. Patients with intermediate-high (n = 29) and intermediate-low (n = 77) PE mortality risk had reduced Ks and prolonged CLT, increased PAI-1 and ETP as compared to low-risk PE (n = 20) patients. Prolonged CLT was predicted by PAI-1 and citH3, while low Ks by C-reactive protein. During a 12-month follow-up 9 (7.1%) patients who had 24% higher ETP, 45% higher citH3 levels, and 18% prolonged CLT at baseline died. High ETP combined with elevated citH3 levels and prolonged CLT was associated with eightfold increased risk of PE-related death. Prothrombotic fibrin clot properties and enhanced neutrophil extracellular traps formation are associated with higher early mortality risk in acute PE patients, which suggests a prognostic role of these biomarkers. |
| format |
article |
| author |
Michał Ząbczyk Joanna Natorska Agnieszka Janion-Sadowska Agnieszka Metzgier-Gumiela Mateusz Polak Krzysztof Plens Marianna Janion Grzegorz Skonieczny Katarzyna Mizia-Stec Anetta Undas |
| author_facet |
Michał Ząbczyk Joanna Natorska Agnieszka Janion-Sadowska Agnieszka Metzgier-Gumiela Mateusz Polak Krzysztof Plens Marianna Janion Grzegorz Skonieczny Katarzyna Mizia-Stec Anetta Undas |
| author_sort |
Michał Ząbczyk |
| title |
Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk |
| title_short |
Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk |
| title_full |
Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk |
| title_fullStr |
Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk |
| title_full_unstemmed |
Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk |
| title_sort |
prothrombotic fibrin clot properties associated with nets formation characterize acute pulmonary embolism patients with higher mortality risk |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/fe63441b4ca843fdbf160c8b3a01c348 |
| work_keys_str_mv |
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