Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

Abstract SARS-CoV-2 infections have been reported in all age groups including infants, children, and adolescents. However, the role of children in the COVID-19 pandemic is still uncertain. This systematic review of early studies synthesises evidence on the susceptibility of children to SARS-CoV-2 in...

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Autores principales:	Katy A. M. Gaythorpe, Sangeeta Bhatia, Tara Mangal, H. Juliette T. Unwin, Natsuko Imai, Gina Cuomo-Dannenburg, Caroline E. Walters, Elita Jauneikaite, Helena Bayley, Mara D. Kont, Andria Mousa, Lilith K. Whittles, Steven Riley, Neil M. Ferguson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe64b7d20c2c46f0a59eb1b1cca2f804
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spelling	oai:doaj.org-article:fe64b7d20c2c46f0a59eb1b1cca2f8042021-12-02T15:22:57ZChildren’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility10.1038/s41598-021-92500-92045-2322https://doaj.org/article/fe64b7d20c2c46f0a59eb1b1cca2f8042021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92500-9https://doaj.org/toc/2045-2322Abstract SARS-CoV-2 infections have been reported in all age groups including infants, children, and adolescents. However, the role of children in the COVID-19 pandemic is still uncertain. This systematic review of early studies synthesises evidence on the susceptibility of children to SARS-CoV-2 infection, the severity and clinical outcomes in children with SARS-CoV-2 infection, and the transmissibility of SARS-CoV-2 by children in the initial phases of the COVID-19 pandemic. A systematic literature review was conducted in PubMed. Reviewers extracted data from relevant, peer-reviewed studies published up to July 4th 2020 during the first wave of the SARS-CoV-2 outbreak using a standardised form and assessed quality using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. For studies included in the meta-analysis, we used a random effects model to calculate pooled estimates of the proportion of children considered asymptomatic or in a severe or critical state. We identified 2775 potential studies of which 128 studies met our inclusion criteria; data were extracted from 99, which were then quality assessed. Finally, 29 studies were considered for the meta-analysis that included information of symptoms and/or severity, these were further assessed based on patient recruitment. Our pooled estimate of the proportion of test positive children who were asymptomatic was 21.1% (95% CI: 14.0–28.1%), based on 13 included studies, and the proportion of children with severe or critical symptoms was 3.8% (95% CI: 1.5–6.0%), based on 14 included studies. We did not identify any studies designed to assess transmissibility in children and found that susceptibility to infection in children was highly variable across studies. Children’s susceptibility to infection and onward transmissibility relative to adults is still unclear and varied widely between studies. However, it is evident that most children experience clinically mild disease or remain asymptomatically infected. More comprehensive contact-tracing studies combined with serosurveys are needed to quantify children’s transmissibility relative to adults. With children back in schools, testing regimes and study protocols that will allow us to better understand the role of children in this pandemic are critical.Katy A. M. GaythorpeSangeeta BhatiaTara MangalH. Juliette T. UnwinNatsuko ImaiGina Cuomo-DannenburgCaroline E. WaltersElita JauneikaiteHelena BayleyMara D. KontAndria MousaLilith K. WhittlesSteven RileyNeil M. FergusonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katy A. M. Gaythorpe Sangeeta Bhatia Tara Mangal H. Juliette T. Unwin Natsuko Imai Gina Cuomo-Dannenburg Caroline E. Walters Elita Jauneikaite Helena Bayley Mara D. Kont Andria Mousa Lilith K. Whittles Steven Riley Neil M. Ferguson Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
description	Abstract SARS-CoV-2 infections have been reported in all age groups including infants, children, and adolescents. However, the role of children in the COVID-19 pandemic is still uncertain. This systematic review of early studies synthesises evidence on the susceptibility of children to SARS-CoV-2 infection, the severity and clinical outcomes in children with SARS-CoV-2 infection, and the transmissibility of SARS-CoV-2 by children in the initial phases of the COVID-19 pandemic. A systematic literature review was conducted in PubMed. Reviewers extracted data from relevant, peer-reviewed studies published up to July 4th 2020 during the first wave of the SARS-CoV-2 outbreak using a standardised form and assessed quality using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. For studies included in the meta-analysis, we used a random effects model to calculate pooled estimates of the proportion of children considered asymptomatic or in a severe or critical state. We identified 2775 potential studies of which 128 studies met our inclusion criteria; data were extracted from 99, which were then quality assessed. Finally, 29 studies were considered for the meta-analysis that included information of symptoms and/or severity, these were further assessed based on patient recruitment. Our pooled estimate of the proportion of test positive children who were asymptomatic was 21.1% (95% CI: 14.0–28.1%), based on 13 included studies, and the proportion of children with severe or critical symptoms was 3.8% (95% CI: 1.5–6.0%), based on 14 included studies. We did not identify any studies designed to assess transmissibility in children and found that susceptibility to infection in children was highly variable across studies. Children’s susceptibility to infection and onward transmissibility relative to adults is still unclear and varied widely between studies. However, it is evident that most children experience clinically mild disease or remain asymptomatically infected. More comprehensive contact-tracing studies combined with serosurveys are needed to quantify children’s transmissibility relative to adults. With children back in schools, testing regimes and study protocols that will allow us to better understand the role of children in this pandemic are critical.
format	article
author	Katy A. M. Gaythorpe Sangeeta Bhatia Tara Mangal H. Juliette T. Unwin Natsuko Imai Gina Cuomo-Dannenburg Caroline E. Walters Elita Jauneikaite Helena Bayley Mara D. Kont Andria Mousa Lilith K. Whittles Steven Riley Neil M. Ferguson
author_facet	Katy A. M. Gaythorpe Sangeeta Bhatia Tara Mangal H. Juliette T. Unwin Natsuko Imai Gina Cuomo-Dannenburg Caroline E. Walters Elita Jauneikaite Helena Bayley Mara D. Kont Andria Mousa Lilith K. Whittles Steven Riley Neil M. Ferguson
author_sort	Katy A. M. Gaythorpe
title	Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
title_short	Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
title_full	Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
title_fullStr	Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
title_full_unstemmed	Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
title_sort	children’s role in the covid-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe64b7d20c2c46f0a59eb1b1cca2f804
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Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

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