Lentiviral vector induces high-quality memory T cells via dendritic cells transduction

Ku et al. report a lentiviral (LV) vector system in which expression of vaccine antigens is driven by β2-microglobulin (β2m) promoter. Conducting comparative studies in mice and rats, they find that LV-based vaccine outperforms the ‘gold-standard’ Ad5 by inducing a polyfunctional and long-lived immu...

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Autores principales:	Min Wen Ku, Pierre Authié, Fabien Nevo, Philippe Souque, Maryline Bourgine, Marta Romano, Pierre Charneau, Laleh Majlessi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fe683d23065d4838988c80289e525fa0
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spelling	oai:doaj.org-article:fe683d23065d4838988c80289e525fa02021-12-02T17:30:53ZLentiviral vector induces high-quality memory T cells via dendritic cells transduction10.1038/s42003-021-02251-62399-3642https://doaj.org/article/fe683d23065d4838988c80289e525fa02021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02251-6https://doaj.org/toc/2399-3642Ku et al. report a lentiviral (LV) vector system in which expression of vaccine antigens is driven by β2-microglobulin (β2m) promoter. Conducting comparative studies in mice and rats, they find that LV-based vaccine outperforms the ‘gold-standard’ Ad5 by inducing a polyfunctional and long-lived immune response.Min Wen KuPierre AuthiéFabien NevoPhilippe SouqueMaryline BourgineMarta RomanoPierre CharneauLaleh MajlessiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Min Wen Ku Pierre Authié Fabien Nevo Philippe Souque Maryline Bourgine Marta Romano Pierre Charneau Laleh Majlessi Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
description	Ku et al. report a lentiviral (LV) vector system in which expression of vaccine antigens is driven by β2-microglobulin (β2m) promoter. Conducting comparative studies in mice and rats, they find that LV-based vaccine outperforms the ‘gold-standard’ Ad5 by inducing a polyfunctional and long-lived immune response.
format	article
author	Min Wen Ku Pierre Authié Fabien Nevo Philippe Souque Maryline Bourgine Marta Romano Pierre Charneau Laleh Majlessi
author_facet	Min Wen Ku Pierre Authié Fabien Nevo Philippe Souque Maryline Bourgine Marta Romano Pierre Charneau Laleh Majlessi
author_sort	Min Wen Ku
title	Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
title_short	Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
title_full	Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
title_fullStr	Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
title_full_unstemmed	Lentiviral vector induces high-quality memory T cells via dendritic cells transduction
title_sort	lentiviral vector induces high-quality memory t cells via dendritic cells transduction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe683d23065d4838988c80289e525fa0
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Lentiviral vector induces high-quality memory T cells via dendritic cells transduction

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