The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus

Background: Strawberries contain high level of antioxidants and polyphenols, especially anthocyanins as powerful antioxidants. These ingredients can recover insulin resistance, oxidative stress, and pancreatic beta-cell function, which can aﬀect blood sugar levels. This study aimed to evaluate the e...

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Autor principal:	Mahendri Deayu Putri
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	homa-ir strawberry type 2 diabetes mellitus rat Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/fe691e0818444ab781fcc3aff0ac1506
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spelling	oai:doaj.org-article:fe691e0818444ab781fcc3aff0ac15062021-11-04T07:40:11ZThe Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus2538-18732538-282910.30476/ijns.2021.92423.1149https://doaj.org/article/fe691e0818444ab781fcc3aff0ac15062021-09-01T00:00:00Zhttps://ijns.sums.ac.ir/article_47806_a758a8580d6382a2a6507751d0a340f8.pdfhttps://doaj.org/toc/2538-1873https://doaj.org/toc/2538-2829Background: Strawberries contain high level of antioxidants and polyphenols, especially anthocyanins as powerful antioxidants. These ingredients can recover insulin resistance, oxidative stress, and pancreatic beta-cell function, which can aﬀect blood sugar levels. This study aimed to evaluate the eﬀect of strawberry juice in recovering insulin resistance in rat model of type 2 diabetes mellitus (T2DM) by homeostatic model assessment of insulin resistance (HOMA-IR) indicators.Methods: In an experimental study, 21 male rats (Rattus norvegicus) of Wistar strain were enrolled and received streptozotocin and nicotinamide to induce DM. They were divided into groups of P1 as negative control group in absence of any treatment, P2 as positive control group that were given metformin HCl (0.9 mg/Kg BW/day), and P3 as intervention group receiving strawberry juice (3.6 mL/200 g BW/day) for 14 days. The HOMA-IR level was determined for all groups and compared.Results: HOMA-IR level in P1 was 8.32±0.26, in P2 was 4.89±0.29, and in P3 was 5.16±0.20. Among groups, prior to treatment, there were no signifcant diﬀerences (p =0.66). A signifcant decrease was noted in HOMA-IR in P2 group (-3.75±0.09; p <0.001) and P3 group (-3.26±0.12; p <0.001), while in P1 group was not signifcant (0.03±0.12; p =0.46).Conclusion: Strawberry fruit like metformin was eﬀective in reducing HOMA-IR in rat model of T2DM, when administered alone.Mahendri Deayu PutriShiraz University of Medical Sciencesarticlehoma-irstrawberrytype 2 diabetes mellitusratNutritional diseases. Deficiency diseasesRC620-627ENInternational Journal of Nutrition Sciences, Vol 6, Iss 3, Pp 134-140 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	homa-ir strawberry type 2 diabetes mellitus rat Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	homa-ir strawberry type 2 diabetes mellitus rat Nutritional diseases. Deficiency diseases RC620-627 Mahendri Deayu Putri The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus
description	Background: Strawberries contain high level of antioxidants and polyphenols, especially anthocyanins as powerful antioxidants. These ingredients can recover insulin resistance, oxidative stress, and pancreatic beta-cell function, which can aﬀect blood sugar levels. This study aimed to evaluate the eﬀect of strawberry juice in recovering insulin resistance in rat model of type 2 diabetes mellitus (T2DM) by homeostatic model assessment of insulin resistance (HOMA-IR) indicators.Methods: In an experimental study, 21 male rats (Rattus norvegicus) of Wistar strain were enrolled and received streptozotocin and nicotinamide to induce DM. They were divided into groups of P1 as negative control group in absence of any treatment, P2 as positive control group that were given metformin HCl (0.9 mg/Kg BW/day), and P3 as intervention group receiving strawberry juice (3.6 mL/200 g BW/day) for 14 days. The HOMA-IR level was determined for all groups and compared.Results: HOMA-IR level in P1 was 8.32±0.26, in P2 was 4.89±0.29, and in P3 was 5.16±0.20. Among groups, prior to treatment, there were no signifcant diﬀerences (p =0.66). A signifcant decrease was noted in HOMA-IR in P2 group (-3.75±0.09; p <0.001) and P3 group (-3.26±0.12; p <0.001), while in P1 group was not signifcant (0.03±0.12; p =0.46).Conclusion: Strawberry fruit like metformin was eﬀective in reducing HOMA-IR in rat model of T2DM, when administered alone.
format	article
author	Mahendri Deayu Putri
author_facet	Mahendri Deayu Putri
author_sort	Mahendri Deayu Putri
title	The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus
title_short	The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus
title_full	The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus
title_fullStr	The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus
title_full_unstemmed	The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus
title_sort	eﬀect of strawberry juice on homa-ir level in rat model of type 2 diabetes mellitus
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/fe691e0818444ab781fcc3aff0ac1506
work_keys_str_mv	AT mahendrideayuputri theeffectofstrawberryjuiceonhomairlevelinratmodeloftype2diabetesmellitus AT mahendrideayuputri effectofstrawberryjuiceonhomairlevelinratmodeloftype2diabetesmellitus
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The Eﬀect of Strawberry Juice on Homa-IR Level in Rat Model of Type 2 Diabetes Mellitus

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