Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease

Abstract It has been known that retinal vein occlusion (RVO) is associated with chronic kidney disease, especially end-stage renal disease (ESRD). However, little is known about the effect of kidney transplantation (KT) on RVO incidence in ESRD patients. This study aimed to compare the incidence of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jangwook Lee, Hye Rim Choe, Sang Hyun Park, Kyung Do Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Eun Kyoung Lee, Un Chul Park, Hyeong Gon Yu, Hajeong Lee, Yong Chul Kim, Baek-Lok Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe700e624e81462e9075b13a10db2301
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fe700e624e81462e9075b13a10db2301
record_format	dspace
spelling	oai:doaj.org-article:fe700e624e81462e9075b13a10db23012021-12-02T15:02:23ZImpact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease10.1038/s41598-021-90765-82045-2322https://doaj.org/article/fe700e624e81462e9075b13a10db23012021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90765-8https://doaj.org/toc/2045-2322Abstract It has been known that retinal vein occlusion (RVO) is associated with chronic kidney disease, especially end-stage renal disease (ESRD). However, little is known about the effect of kidney transplantation (KT) on RVO incidence in ESRD patients. This study aimed to compare the incidence of RVO in KT recipients (n = 10,498), matched ESRD patients (n = 10,498), and healthy controls (HCs, n = 10,498), using a long-term population-based cohort. The incidence of RVO was 2.74, 5.68, and 1.02 per 1000 patient-years, for the KT group, the ESRD group, and the HCs group, respectively. Adjusted hazard ratios for RVO development compared to the HCs group, were 1.53 and 3.21, in the KT group and the ESRD group, respectively. In the KT group, multivariable regression analysis indicated that an age over 50, a Charlson Comorbidity Index score over 4, and a history of desensitization therapy were associated with an increased risk of RVO. In summary, KT recipients have a lower risk for development of RVO than ESRD patients treated with dialysis. However, the risk is still higher compared to healthy people who have normal kidney functions.Jangwook LeeHye Rim ChoeSang Hyun ParkKyung Do HanDong Ki KimKwon Wook JooYon Su KimEun Kyoung LeeUn Chul ParkHyeong Gon YuHajeong LeeYong Chul KimBaek-Lok OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jangwook Lee Hye Rim Choe Sang Hyun Park Kyung Do Han Dong Ki Kim Kwon Wook Joo Yon Su Kim Eun Kyoung Lee Un Chul Park Hyeong Gon Yu Hajeong Lee Yong Chul Kim Baek-Lok Oh Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
description	Abstract It has been known that retinal vein occlusion (RVO) is associated with chronic kidney disease, especially end-stage renal disease (ESRD). However, little is known about the effect of kidney transplantation (KT) on RVO incidence in ESRD patients. This study aimed to compare the incidence of RVO in KT recipients (n = 10,498), matched ESRD patients (n = 10,498), and healthy controls (HCs, n = 10,498), using a long-term population-based cohort. The incidence of RVO was 2.74, 5.68, and 1.02 per 1000 patient-years, for the KT group, the ESRD group, and the HCs group, respectively. Adjusted hazard ratios for RVO development compared to the HCs group, were 1.53 and 3.21, in the KT group and the ESRD group, respectively. In the KT group, multivariable regression analysis indicated that an age over 50, a Charlson Comorbidity Index score over 4, and a history of desensitization therapy were associated with an increased risk of RVO. In summary, KT recipients have a lower risk for development of RVO than ESRD patients treated with dialysis. However, the risk is still higher compared to healthy people who have normal kidney functions.
format	article
author	Jangwook Lee Hye Rim Choe Sang Hyun Park Kyung Do Han Dong Ki Kim Kwon Wook Joo Yon Su Kim Eun Kyoung Lee Un Chul Park Hyeong Gon Yu Hajeong Lee Yong Chul Kim Baek-Lok Oh
author_facet	Jangwook Lee Hye Rim Choe Sang Hyun Park Kyung Do Han Dong Ki Kim Kwon Wook Joo Yon Su Kim Eun Kyoung Lee Un Chul Park Hyeong Gon Yu Hajeong Lee Yong Chul Kim Baek-Lok Oh
author_sort	Jangwook Lee
title	Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
title_short	Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
title_full	Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
title_fullStr	Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
title_full_unstemmed	Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
title_sort	impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe700e624e81462e9075b13a10db2301
work_keys_str_mv	AT jangwooklee impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT hyerimchoe impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT sanghyunpark impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT kyungdohan impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT dongkikim impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT kwonwookjoo impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT yonsukim impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT eunkyounglee impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT unchulpark impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT hyeonggonyu impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT hajeonglee impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT yongchulkim impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease AT baeklokoh impactofkidneytransplantationontheriskofretinalveinocclusioninendstagerenaldisease
_version_	1718389116269232128

Impact of kidney transplantation on the risk of retinal vein occlusion in end-stage renal disease

Ejemplares similares