The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms

The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms

Paediatric therapy-related myeloid neoplasms (tMN) have a dismal prognosis and have not been comprehensively profiled. Here the authors characterise the molecular landscape of 84 paediatric tMN patients, and find that, unlike adult tMNs, these do not emerge from pre-existing clones and that MECOM dy...

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Autores principales: Jason R. Schwartz, Jing Ma, Jennifer Kamens, Tamara Westover, Michael P. Walsh, Samuel W. Brady, J. Robert Michael, Xiaolong Chen, Lindsey Montefiori, Guangchun Song, Gang Wu, Huiyun Wu, Cristyn Branstetter, Ryan Hiltenbrand, Michael F. Walsh, Kim E. Nichols, Jamie L. Maciaszek, Yanling Liu, Priyadarshini Kumar, John Easton, Scott Newman, Jeffrey E. Rubnitz, Charles G. Mullighan, Stanley Pounds, Jinghui Zhang, Tanja Gruber, Xiaotu Ma, Jeffery M. Klco
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fe707965968044aaa183257f76774e4d
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spelling oai:doaj.org-article:fe707965968044aaa183257f76774e4d2021-12-02T14:26:51ZThe acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms10.1038/s41467-021-21255-82041-1723https://doaj.org/article/fe707965968044aaa183257f76774e4d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21255-8https://doaj.org/toc/2041-1723Paediatric therapy-related myeloid neoplasms (tMN) have a dismal prognosis and have not been comprehensively profiled. Here the authors characterise the molecular landscape of 84 paediatric tMN patients, and find that, unlike adult tMNs, these do not emerge from pre-existing clones and that MECOM dysregulation is frequent.Jason R. SchwartzJing MaJennifer KamensTamara WestoverMichael P. WalshSamuel W. BradyJ. Robert MichaelXiaolong ChenLindsey MontefioriGuangchun SongGang WuHuiyun WuCristyn BranstetterRyan HiltenbrandMichael F. WalshKim E. NicholsJamie L. MaciaszekYanling LiuPriyadarshini KumarJohn EastonScott NewmanJeffrey E. RubnitzCharles G. MullighanStanley PoundsJinghui ZhangTanja GruberXiaotu MaJeffery M. KlcoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jason R. Schwartz
Jing Ma
Jennifer Kamens
Tamara Westover
Michael P. Walsh
Samuel W. Brady
J. Robert Michael
Xiaolong Chen
Lindsey Montefiori
Guangchun Song
Gang Wu
Huiyun Wu
Cristyn Branstetter
Ryan Hiltenbrand
Michael F. Walsh
Kim E. Nichols
Jamie L. Maciaszek
Yanling Liu
Priyadarshini Kumar
John Easton
Scott Newman
Jeffrey E. Rubnitz
Charles G. Mullighan
Stanley Pounds
Jinghui Zhang
Tanja Gruber
Xiaotu Ma
Jeffery M. Klco
The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
description Paediatric therapy-related myeloid neoplasms (tMN) have a dismal prognosis and have not been comprehensively profiled. Here the authors characterise the molecular landscape of 84 paediatric tMN patients, and find that, unlike adult tMNs, these do not emerge from pre-existing clones and that MECOM dysregulation is frequent.
format article
author Jason R. Schwartz
Jing Ma
Jennifer Kamens
Tamara Westover
Michael P. Walsh
Samuel W. Brady
J. Robert Michael
Xiaolong Chen
Lindsey Montefiori
Guangchun Song
Gang Wu
Huiyun Wu
Cristyn Branstetter
Ryan Hiltenbrand
Michael F. Walsh
Kim E. Nichols
Jamie L. Maciaszek
Yanling Liu
Priyadarshini Kumar
John Easton
Scott Newman
Jeffrey E. Rubnitz
Charles G. Mullighan
Stanley Pounds
Jinghui Zhang
Tanja Gruber
Xiaotu Ma
Jeffery M. Klco
author_facet Jason R. Schwartz
Jing Ma
Jennifer Kamens
Tamara Westover
Michael P. Walsh
Samuel W. Brady
J. Robert Michael
Xiaolong Chen
Lindsey Montefiori
Guangchun Song
Gang Wu
Huiyun Wu
Cristyn Branstetter
Ryan Hiltenbrand
Michael F. Walsh
Kim E. Nichols
Jamie L. Maciaszek
Yanling Liu
Priyadarshini Kumar
John Easton
Scott Newman
Jeffrey E. Rubnitz
Charles G. Mullighan
Stanley Pounds
Jinghui Zhang
Tanja Gruber
Xiaotu Ma
Jeffery M. Klco
author_sort Jason R. Schwartz
title The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
title_short The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
title_full The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
title_fullStr The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
title_full_unstemmed The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
title_sort acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fe707965968044aaa183257f76774e4d
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