Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes

BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using inflammatory markers, facilitating the selection of the optimal treatment strategy....

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Autores principales:	Carlos Cerdan-Santacruz, Laia Codina-Corrons, Mireia Merichal-Resina, Lucia Milla-Collado, Javier Trujillano-Cabello, Jordi Tarragona-Foradada, Nuria Mestres-Petit, Enrique Sierra-Grañón, Jorge Olsina-Kissler
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	pathologic complete response neoadjuvant chemoradiotherapy inflammatory indexes neutrophil rectal cancer tumor regression Medicine R
Acceso en línea:	https://doaj.org/article/fe71687fd8eb4581b9a38906ffc40fbf
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spelling	oai:doaj.org-article:fe71687fd8eb4581b9a38906ffc40fbf2021-11-14T06:50:55ZFactors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes2783-243010.30476/acrr.2021.47811https://doaj.org/article/fe71687fd8eb4581b9a38906ffc40fbf2021-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47811_f465c45bad7ae67ac80335a8730d3845.pdfhttps://doaj.org/toc/2783-2430BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using inflammatory markers, facilitating the selection of the optimal treatment strategy. METHODS: Patients undergoing primary tumor resection after long-cycle NCRT at a single center (2012 to 2018) were retrospectively collected (n=130). Patient demographics, preoperative laboratory measurements, tumor characteristics, treatment strategy, and postoperative anatomopathological variables were collected. The association of factors to pCR was examined using binary logistic regression, odds ratio (OR) (95% confidence interval), and the discriminative capacity with the ROC curve. RESULTS: Out of 130 patients, 42 pCRs occurred, equal to 32.3% of the sample. Variables identified as useful to predict pCR were total neutrophil count (3; OR 7.6), intravenous 5-FU chemotherapy strategy (OR 3.2), and absence of diabetes (OR 3.4). Patients having all three of them had a 55.3% chance of pCR. CONCLUSIONS: The absolute neutrophil count better predicts pCR than other inflammatory indices in selected patients with LARC undergoing long-cycle NCRT. A neutrophil count less than 6400 cells/mm3, absence of diabetes, and intravenous 5-FU NCRT therapy lead to a relative rise in pCR.Carlos Cerdan-SantacruzLaia Codina-CorronsMireia Merichal-ResinaLucia Milla-ColladoJavier Trujillano-CabelloJordi Tarragona-ForadadaNuria Mestres-PetitEnrique Sierra-GrañónJorge Olsina-KisslerShiraz University of Medical Sciencesarticlepathologic complete responseneoadjuvant chemoradiotherapyinflammatory indexesneutrophilrectal cancertumor regressionMedicineRENIranian Journal of Colorectal Research, Vol 9, Iss 3, Pp 90-97 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pathologic complete response neoadjuvant chemoradiotherapy inflammatory indexes neutrophil rectal cancer tumor regression Medicine R
spellingShingle	pathologic complete response neoadjuvant chemoradiotherapy inflammatory indexes neutrophil rectal cancer tumor regression Medicine R Carlos Cerdan-Santacruz Laia Codina-Corrons Mireia Merichal-Resina Lucia Milla-Collado Javier Trujillano-Cabello Jordi Tarragona-Foradada Nuria Mestres-Petit Enrique Sierra-Grañón Jorge Olsina-Kissler Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
description	BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using inflammatory markers, facilitating the selection of the optimal treatment strategy. METHODS: Patients undergoing primary tumor resection after long-cycle NCRT at a single center (2012 to 2018) were retrospectively collected (n=130). Patient demographics, preoperative laboratory measurements, tumor characteristics, treatment strategy, and postoperative anatomopathological variables were collected. The association of factors to pCR was examined using binary logistic regression, odds ratio (OR) (95% confidence interval), and the discriminative capacity with the ROC curve. RESULTS: Out of 130 patients, 42 pCRs occurred, equal to 32.3% of the sample. Variables identified as useful to predict pCR were total neutrophil count (3; OR 7.6), intravenous 5-FU chemotherapy strategy (OR 3.2), and absence of diabetes (OR 3.4). Patients having all three of them had a 55.3% chance of pCR. CONCLUSIONS: The absolute neutrophil count better predicts pCR than other inflammatory indices in selected patients with LARC undergoing long-cycle NCRT. A neutrophil count less than 6400 cells/mm3, absence of diabetes, and intravenous 5-FU NCRT therapy lead to a relative rise in pCR.
format	article
author	Carlos Cerdan-Santacruz Laia Codina-Corrons Mireia Merichal-Resina Lucia Milla-Collado Javier Trujillano-Cabello Jordi Tarragona-Foradada Nuria Mestres-Petit Enrique Sierra-Grañón Jorge Olsina-Kissler
author_facet	Carlos Cerdan-Santacruz Laia Codina-Corrons Mireia Merichal-Resina Lucia Milla-Collado Javier Trujillano-Cabello Jordi Tarragona-Foradada Nuria Mestres-Petit Enrique Sierra-Grañón Jorge Olsina-Kissler
author_sort	Carlos Cerdan-Santacruz
title	Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
title_short	Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
title_full	Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
title_fullStr	Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
title_full_unstemmed	Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes
title_sort	factors associated with higher rate of complete pathologic response after long-course neoadjuvant treatment for locally advanced rectal cancer patients – results from a retrospective cohort study focused on inflammatory indexes
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/fe71687fd8eb4581b9a38906ffc40fbf
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Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes

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