Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease

Observational studies indicate that selenium may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Transcriptomic exploration of the aetiology and progression of NAFLD may offer insight into the role selenium plays in this disease. This study compared gene expression level...

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Autores principales:	Kaitlin Day, Lucia A. Seale, Ross M. Graham, Barbara R. Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	selenium non-alcoholic steatohepatitis selenoproteins selenocysteine lyase ferroptosis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/fe723a87500e4b72b2c8090ef0e53873
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spelling	oai:doaj.org-article:fe723a87500e4b72b2c8090ef0e538732021-11-17T06:36:42ZSelenotranscriptome Network in Non-alcoholic Fatty Liver Disease2296-861X10.3389/fnut.2021.744825https://doaj.org/article/fe723a87500e4b72b2c8090ef0e538732021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.744825/fullhttps://doaj.org/toc/2296-861XObservational studies indicate that selenium may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Transcriptomic exploration of the aetiology and progression of NAFLD may offer insight into the role selenium plays in this disease. This study compared gene expression levels of known selenoprotein pathways between individuals with a healthy liver to those with NAFLD. Publicly available gene expression databases were searched for studies that measured global gene expression in liver samples from patients with steatosis and non-alcoholic steatohepatitis (NASH) and healthy controls (with [HOC] or without [HC] obesity). A subset of five selenoprotein-related pathways (164 genes) were assessed in the four datasets included in this analysis. The gene TXNRD3 was less expressed in both disease groups when compared with HOC. SCLY and SELENOO were less expressed in NASH when compared with HC. SELENOM, DIO1, GPX2, and GPX3 were highly expressed in NASH when compared to HOC. Disease groups had lower expression of iron-associated transporters and higher expression of ferritin-encoding sub-units, consistent with dysregulation of iron metabolism often observed in NAFLD. Our bioinformatics analysis suggests that the NAFLD liver may have lower selenium levels than a disease-free liver, which may be associated with a disrupted iron metabolism. Our findings indicate that gene expression variation may be associated with the progressive risk of NAFLD.Kaitlin DayLucia A. SealeRoss M. GrahamBarbara R. CardosoFrontiers Media S.A.articleseleniumnon-alcoholic steatohepatitisselenoproteinsselenocysteine lyaseferroptosisNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium non-alcoholic steatohepatitis selenoproteins selenocysteine lyase ferroptosis Nutrition. Foods and food supply TX341-641
spellingShingle	selenium non-alcoholic steatohepatitis selenoproteins selenocysteine lyase ferroptosis Nutrition. Foods and food supply TX341-641 Kaitlin Day Lucia A. Seale Ross M. Graham Barbara R. Cardoso Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
description	Observational studies indicate that selenium may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Transcriptomic exploration of the aetiology and progression of NAFLD may offer insight into the role selenium plays in this disease. This study compared gene expression levels of known selenoprotein pathways between individuals with a healthy liver to those with NAFLD. Publicly available gene expression databases were searched for studies that measured global gene expression in liver samples from patients with steatosis and non-alcoholic steatohepatitis (NASH) and healthy controls (with [HOC] or without [HC] obesity). A subset of five selenoprotein-related pathways (164 genes) were assessed in the four datasets included in this analysis. The gene TXNRD3 was less expressed in both disease groups when compared with HOC. SCLY and SELENOO were less expressed in NASH when compared with HC. SELENOM, DIO1, GPX2, and GPX3 were highly expressed in NASH when compared to HOC. Disease groups had lower expression of iron-associated transporters and higher expression of ferritin-encoding sub-units, consistent with dysregulation of iron metabolism often observed in NAFLD. Our bioinformatics analysis suggests that the NAFLD liver may have lower selenium levels than a disease-free liver, which may be associated with a disrupted iron metabolism. Our findings indicate that gene expression variation may be associated with the progressive risk of NAFLD.
format	article
author	Kaitlin Day Lucia A. Seale Ross M. Graham Barbara R. Cardoso
author_facet	Kaitlin Day Lucia A. Seale Ross M. Graham Barbara R. Cardoso
author_sort	Kaitlin Day
title	Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
title_short	Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
title_full	Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
title_fullStr	Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
title_full_unstemmed	Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease
title_sort	selenotranscriptome network in non-alcoholic fatty liver disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fe723a87500e4b72b2c8090ef0e53873
work_keys_str_mv	AT kaitlinday selenotranscriptomenetworkinnonalcoholicfattyliverdisease AT luciaaseale selenotranscriptomenetworkinnonalcoholicfattyliverdisease AT rossmgraham selenotranscriptomenetworkinnonalcoholicfattyliverdisease AT barbararcardoso selenotranscriptomenetworkinnonalcoholicfattyliverdisease
_version_	1718425904248520704

Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease

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