Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be required for cilia signaling.

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Autores principales:	Kai He, Xiaoyu Ma, Tao Xu, Yan Li, Allen Hodge, Qing Zhang, Julia Torline, Yan Huang, Jian Zhao, Kun Ling, Jinghua Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe748722a15345dcb5d0de9358f9625b
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spelling	oai:doaj.org-article:fe748722a15345dcb5d0de9358f9625b2021-12-02T15:33:47ZAxoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules10.1038/s41467-018-05867-12041-1723https://doaj.org/article/fe748722a15345dcb5d0de9358f9625b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05867-1https://doaj.org/toc/2041-1723The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be required for cilia signaling.Kai HeXiaoyu MaTao XuYan LiAllen HodgeQing ZhangJulia TorlineYan HuangJian ZhaoKun LingJinghua HuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai He Xiaoyu Ma Tao Xu Yan Li Allen Hodge Qing Zhang Julia Torline Yan Huang Jian Zhao Kun Ling Jinghua Hu Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
description	The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be required for cilia signaling.
format	article
author	Kai He Xiaoyu Ma Tao Xu Yan Li Allen Hodge Qing Zhang Julia Torline Yan Huang Jian Zhao Kun Ling Jinghua Hu
author_facet	Kai He Xiaoyu Ma Tao Xu Yan Li Allen Hodge Qing Zhang Julia Torline Yan Huang Jian Zhao Kun Ling Jinghua Hu
author_sort	Kai He
title	Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
title_short	Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
title_full	Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
title_fullStr	Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
title_full_unstemmed	Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
title_sort	axoneme polyglutamylation regulated by joubert syndrome protein arl13b controls ciliary targeting of signaling molecules
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe748722a15345dcb5d0de9358f9625b
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_version_	1718387062250405888

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

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