Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300
PurposeThis study represents a descriptive analysis of preliminary results of a Phase II trial on a novel mixed beam radiotherapy (RT) approach, consisting of carbon ions RT (CIRT) followed by intensity-modulated photon RT, in combination with hormonal therapy, for high-risk prostate cancer (HR PCa)...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:fe76b859e37540c1ac9f11af84dce1fc2021-11-17T07:04:12ZMixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-143002234-943X10.3389/fonc.2021.778729https://doaj.org/article/fe76b859e37540c1ac9f11af84dce1fc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.778729/fullhttps://doaj.org/toc/2234-943XPurposeThis study represents a descriptive analysis of preliminary results of a Phase II trial on a novel mixed beam radiotherapy (RT) approach, consisting of carbon ions RT (CIRT) followed by intensity-modulated photon RT, in combination with hormonal therapy, for high-risk prostate cancer (HR PCa) with a special focus on acute toxicity.MethodsPrimary endpoint was the evaluation of safety in terms of acute toxicity. Secondary endpoints were early and long-term tolerability of treatment, quality of life (QoL), and efficacy. Data on acute and late toxicities were collected according to RTOG/EORTC. QoL of enrolled patients was assessed by IPSS, EORTC QLQ-C30, EORTC QLQ-PR25, and sexual activity by IIEF-5.ResultsTwenty-six patients were enrolled in the study, but only 15 completed so far the RT course and were included. Immediately after CIRT, no patients experienced GI/GU toxicity. At 1 and 3 months from the whole course RT completion, no GI/GU toxicities greater than grade 2 were observed. QoL scores were overall satisfactory.ConclusionsThe feasibility of the proposed mixed treatment schedule was assessed, and an excellent acute toxicity profile was recorded. Such findings instil confidence in the continuation of this mixed approach, with evaluation of long-term tolerability and efficacy.Giulia MarvasoGiulia MarvasoBarbara VischioniMatteo PepaMattia ZaffaroniStefania VolpeStefania VolpeFilippo PattiFilippo PattiFederica BellerbaSara GandiniStefania ComiGiulia CorraoGiulia CorraoDario ZeriniMatteo AugugliaroCristiana FodorStefania RussoSilvia MolinelliMario CioccaRosalinda RicottiFrancesca ValvoTommaso GiandiniBarbara AvuzziRiccardo ValdagniRiccardo ValdagniOttavio De CobelliOttavio De CobelliFederica CattaniEster OrlandiBarbara Alicja Jereczek-FossaBarbara Alicja Jereczek-FossaRoberto OrecchiaFrontiers Media S.A.articlecarbon-ion radiotherapyintensity modulated radiotherapyhigh-risk prostate cancerphase II studymixed-beam approachNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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| topic |
carbon-ion radiotherapy intensity modulated radiotherapy high-risk prostate cancer phase II study mixed-beam approach Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
carbon-ion radiotherapy intensity modulated radiotherapy high-risk prostate cancer phase II study mixed-beam approach Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Giulia Marvaso Giulia Marvaso Barbara Vischioni Matteo Pepa Mattia Zaffaroni Stefania Volpe Stefania Volpe Filippo Patti Filippo Patti Federica Bellerba Sara Gandini Stefania Comi Giulia Corrao Giulia Corrao Dario Zerini Matteo Augugliaro Cristiana Fodor Stefania Russo Silvia Molinelli Mario Ciocca Rosalinda Ricotti Francesca Valvo Tommaso Giandini Barbara Avuzzi Riccardo Valdagni Riccardo Valdagni Ottavio De Cobelli Ottavio De Cobelli Federica Cattani Ester Orlandi Barbara Alicja Jereczek-Fossa Barbara Alicja Jereczek-Fossa Roberto Orecchia Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300 |
| description |
PurposeThis study represents a descriptive analysis of preliminary results of a Phase II trial on a novel mixed beam radiotherapy (RT) approach, consisting of carbon ions RT (CIRT) followed by intensity-modulated photon RT, in combination with hormonal therapy, for high-risk prostate cancer (HR PCa) with a special focus on acute toxicity.MethodsPrimary endpoint was the evaluation of safety in terms of acute toxicity. Secondary endpoints were early and long-term tolerability of treatment, quality of life (QoL), and efficacy. Data on acute and late toxicities were collected according to RTOG/EORTC. QoL of enrolled patients was assessed by IPSS, EORTC QLQ-C30, EORTC QLQ-PR25, and sexual activity by IIEF-5.ResultsTwenty-six patients were enrolled in the study, but only 15 completed so far the RT course and were included. Immediately after CIRT, no patients experienced GI/GU toxicity. At 1 and 3 months from the whole course RT completion, no GI/GU toxicities greater than grade 2 were observed. QoL scores were overall satisfactory.ConclusionsThe feasibility of the proposed mixed treatment schedule was assessed, and an excellent acute toxicity profile was recorded. Such findings instil confidence in the continuation of this mixed approach, with evaluation of long-term tolerability and efficacy. |
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article |
| author |
Giulia Marvaso Giulia Marvaso Barbara Vischioni Matteo Pepa Mattia Zaffaroni Stefania Volpe Stefania Volpe Filippo Patti Filippo Patti Federica Bellerba Sara Gandini Stefania Comi Giulia Corrao Giulia Corrao Dario Zerini Matteo Augugliaro Cristiana Fodor Stefania Russo Silvia Molinelli Mario Ciocca Rosalinda Ricotti Francesca Valvo Tommaso Giandini Barbara Avuzzi Riccardo Valdagni Riccardo Valdagni Ottavio De Cobelli Ottavio De Cobelli Federica Cattani Ester Orlandi Barbara Alicja Jereczek-Fossa Barbara Alicja Jereczek-Fossa Roberto Orecchia |
| author_facet |
Giulia Marvaso Giulia Marvaso Barbara Vischioni Matteo Pepa Mattia Zaffaroni Stefania Volpe Stefania Volpe Filippo Patti Filippo Patti Federica Bellerba Sara Gandini Stefania Comi Giulia Corrao Giulia Corrao Dario Zerini Matteo Augugliaro Cristiana Fodor Stefania Russo Silvia Molinelli Mario Ciocca Rosalinda Ricotti Francesca Valvo Tommaso Giandini Barbara Avuzzi Riccardo Valdagni Riccardo Valdagni Ottavio De Cobelli Ottavio De Cobelli Federica Cattani Ester Orlandi Barbara Alicja Jereczek-Fossa Barbara Alicja Jereczek-Fossa Roberto Orecchia |
| author_sort |
Giulia Marvaso |
| title |
Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300 |
| title_short |
Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300 |
| title_full |
Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300 |
| title_fullStr |
Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300 |
| title_full_unstemmed |
Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300 |
| title_sort |
mixed-beam approach for high-risk prostate cancer carbon-ion boost followed by photon intensity-modulated radiotherapy: preliminary results of phase ii trial airc-ig-14300 |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/fe76b859e37540c1ac9f11af84dce1fc |
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