The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men

Layla B Guscoth,1 Sarah L Appleton,2 Sean A Martin,1 Robert J Adams,2 Yohannes A Melaku,2 Gary A Wittert1 1Freemasons Centre for Male Health and Well-Being, South Australian Health and Medical Research Institute and Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Aust...

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Autores principales:	Guscoth LB, Appleton SL, Martin SA, Adams RJ, Melaku YA, Wittert GA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obstructive sleep apnea triglycerides hypoxemia cohort studies men visceral obesity Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/fe7bb982807d4aa3b2661ebe6b05c854
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spelling	oai:doaj.org-article:fe7bb982807d4aa3b2661ebe6b05c8542021-12-02T18:35:52ZThe Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men1179-1608https://doaj.org/article/fe7bb982807d4aa3b2661ebe6b05c8542021-10-01T00:00:00Zhttps://www.dovepress.com/the-association-of-obstructive-sleep-apnea-and-nocturnal-hypoxemia-wit-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Layla B Guscoth,1 Sarah L Appleton,2 Sean A Martin,1 Robert J Adams,2 Yohannes A Melaku,2 Gary A Wittert1 1Freemasons Centre for Male Health and Well-Being, South Australian Health and Medical Research Institute and Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, 5000, Australia; 2Flinders Health and Medical Research Institute (Sleep Health, Formerly the Adelaide Institute for Sleep Health) A Flinders Centre of Research Excellence, Flinders University, Adelaide, South Australia, 5042, AustraliaCorrespondence: Sarah L AppletonFlinders Health and Medical Research Institute (Sleep Health, formerly the Adelaide Institute for Sleep Health) A Flinders Centre of Research Excellence, Flinders University, Bedford Park, Adelaide, South Australia, 5042, AustraliaEmail sarah.appleton@flinders.edu.auObjective: To determine the association of obstructive sleep apnea and nocturnal hypoxemia with serum lipid profiles in unselected community-dwelling men.Methods: Cross-sectional data from participants of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study (n=753) who underwent full in-home polysomnography (Embletta X100) was used. Triglycerides, high- (HDL), low-density lipoprotein (LDL), and total cholesterol were assessed on a fasting morning blood sample. Multivariable linear regression analyses assessed associations between lipids and continuous measures of nocturnal hypoxemia (oxygen desaturation index (3%) (ODI), apnea–hypopnea index (AHI), and rapid eye movement sleep apnea–hypopnea index (REM-AHI)), adjusted for chronic conditions, risk behavior and sociodemographic factors. Sensitivity analyses examined the effect of lipid lowering therapies on reported estimates. Effect modification was examined through stratification by waist circumference groups.Results: In 753 participants with mean (SD) age of 60.8 (10.9) years and waist circumference: 99.3 (11.6) cm, the prevalence of OSA (AHI≥ 10) was 52.6%. Overall, no significant associations between OSA metrics and lipid measures were found. Similarly, sensitivity analysis excluding lipid lowering therapies showed no significant associations. In analysis stratified by waist circumference (< 95cm, 95– 100cm, > 100cm), ODI (3%, unstandardized B: 0.027, 95% CI: 0.015– 0.040), AHI (0.023, 0.012– 0.033) and AHIREM (0.012, 0.001– 0.022) were positively associated with serum triglycerides in participants with a normal waist circumference (< 95cm).Conclusion: Obstructive sleep apnea metrics were positively associated with serum triglyceride levels in men with a normal waist circumference. Healthy weight individuals with OSA require clinical attention to improve cardiometabolic risk profiles.Keywords: obstructive sleep apnea, triglycerides, hypoxemia, cohort studies, men, visceral obesityGuscoth LBAppleton SLMartin SAAdams RJMelaku YAWittert GADove Medical Pressarticleobstructive sleep apneatriglycerideshypoxemiacohort studiesmenvisceral obesityPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1771-1782 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea triglycerides hypoxemia cohort studies men visceral obesity Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	obstructive sleep apnea triglycerides hypoxemia cohort studies men visceral obesity Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Guscoth LB Appleton SL Martin SA Adams RJ Melaku YA Wittert GA The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
description	Layla B Guscoth,1 Sarah L Appleton,2 Sean A Martin,1 Robert J Adams,2 Yohannes A Melaku,2 Gary A Wittert1 1Freemasons Centre for Male Health and Well-Being, South Australian Health and Medical Research Institute and Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, 5000, Australia; 2Flinders Health and Medical Research Institute (Sleep Health, Formerly the Adelaide Institute for Sleep Health) A Flinders Centre of Research Excellence, Flinders University, Adelaide, South Australia, 5042, AustraliaCorrespondence: Sarah L AppletonFlinders Health and Medical Research Institute (Sleep Health, formerly the Adelaide Institute for Sleep Health) A Flinders Centre of Research Excellence, Flinders University, Bedford Park, Adelaide, South Australia, 5042, AustraliaEmail sarah.appleton@flinders.edu.auObjective: To determine the association of obstructive sleep apnea and nocturnal hypoxemia with serum lipid profiles in unselected community-dwelling men.Methods: Cross-sectional data from participants of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study (n=753) who underwent full in-home polysomnography (Embletta X100) was used. Triglycerides, high- (HDL), low-density lipoprotein (LDL), and total cholesterol were assessed on a fasting morning blood sample. Multivariable linear regression analyses assessed associations between lipids and continuous measures of nocturnal hypoxemia (oxygen desaturation index (3%) (ODI), apnea–hypopnea index (AHI), and rapid eye movement sleep apnea–hypopnea index (REM-AHI)), adjusted for chronic conditions, risk behavior and sociodemographic factors. Sensitivity analyses examined the effect of lipid lowering therapies on reported estimates. Effect modification was examined through stratification by waist circumference groups.Results: In 753 participants with mean (SD) age of 60.8 (10.9) years and waist circumference: 99.3 (11.6) cm, the prevalence of OSA (AHI≥ 10) was 52.6%. Overall, no significant associations between OSA metrics and lipid measures were found. Similarly, sensitivity analysis excluding lipid lowering therapies showed no significant associations. In analysis stratified by waist circumference (< 95cm, 95– 100cm, > 100cm), ODI (3%, unstandardized B: 0.027, 95% CI: 0.015– 0.040), AHI (0.023, 0.012– 0.033) and AHIREM (0.012, 0.001– 0.022) were positively associated with serum triglycerides in participants with a normal waist circumference (< 95cm).Conclusion: Obstructive sleep apnea metrics were positively associated with serum triglyceride levels in men with a normal waist circumference. Healthy weight individuals with OSA require clinical attention to improve cardiometabolic risk profiles.Keywords: obstructive sleep apnea, triglycerides, hypoxemia, cohort studies, men, visceral obesity
format	article
author	Guscoth LB Appleton SL Martin SA Adams RJ Melaku YA Wittert GA
author_facet	Guscoth LB Appleton SL Martin SA Adams RJ Melaku YA Wittert GA
author_sort	Guscoth LB
title	The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
title_short	The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
title_full	The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
title_fullStr	The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
title_full_unstemmed	The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men
title_sort	association of obstructive sleep apnea and nocturnal hypoxemia with lipid profiles in a population-based study of community-dwelling australian men
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/fe7bb982807d4aa3b2661ebe6b05c854
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The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with Lipid Profiles in a Population-Based Study of Community-Dwelling Australian Men

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