Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques.
Pandemic (H1N1) 2009 influenza virus spread throughout the world since most people did not have immunity against the virus. In the post pandemic phase when many humans might possess immunity against the pandemic virus, one of the concerns is infection in immunocompromised people. Therefore, we used...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/fe7c12e73f794def8635ea8987099fdb |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:fe7c12e73f794def8635ea8987099fdb |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:fe7c12e73f794def8635ea8987099fdb2021-11-18T08:54:13ZPathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques.1932-620310.1371/journal.pone.0075910https://doaj.org/article/fe7c12e73f794def8635ea8987099fdb2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086663/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Pandemic (H1N1) 2009 influenza virus spread throughout the world since most people did not have immunity against the virus. In the post pandemic phase when many humans might possess immunity against the pandemic virus, one of the concerns is infection in immunocompromised people. Therefore, we used an immunosuppressed macaque model to examine pathogenicity of the pandemic (H1N1) 2009 virus under an immunocompromised condition. The virus in nasal samples of immunosuppressed macaques infected with the pandemic (H1N1) 2009 virus was detected longer after infection than was the virus in nasal samples of immunocompetent macaques. As expected, not only virus amounts but also virus propagation sites in the immunosuppressed macaques were larger than those in lungs of the immunocompetent macaques when they were infected with the pandemic virus. Immunosuppressed macaques possessed low levels of immune cells producing cytokines and chemokines, but levels of inflammatory cytokines/chemokine interleukin (IL)-6, IL-18, and monocyte chemotactic protein (MCP)-1 in lungs of the immunosuppressed macaques were higher than those in lungs of the immunocompetent macaques, though the differences were not statistically significant. Therefore, under an immunosuppressive condition, the pandemic influenza (H1N1) 2009 virus might cause more severe morbidity with high cytokine/chemokine production by the host innate immune system than that seen in macaques under the immunocompetent condition.Van Loi PhamMisako NakayamaYasushi ItohHirohito IshigakiMitsutaka KitanoMasahiko ArikataHideaki IshidaNaoko KitagawaShintaro ShichinoheMasatoshi OkamatsuYoshihiro SakodaHideaki TsuchiyaShinichiro NakamuraHiroshi KidaKazumasa OgasawaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75910 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Van Loi Pham Misako Nakayama Yasushi Itoh Hirohito Ishigaki Mitsutaka Kitano Masahiko Arikata Hideaki Ishida Naoko Kitagawa Shintaro Shichinohe Masatoshi Okamatsu Yoshihiro Sakoda Hideaki Tsuchiya Shinichiro Nakamura Hiroshi Kida Kazumasa Ogasawara Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. |
| description |
Pandemic (H1N1) 2009 influenza virus spread throughout the world since most people did not have immunity against the virus. In the post pandemic phase when many humans might possess immunity against the pandemic virus, one of the concerns is infection in immunocompromised people. Therefore, we used an immunosuppressed macaque model to examine pathogenicity of the pandemic (H1N1) 2009 virus under an immunocompromised condition. The virus in nasal samples of immunosuppressed macaques infected with the pandemic (H1N1) 2009 virus was detected longer after infection than was the virus in nasal samples of immunocompetent macaques. As expected, not only virus amounts but also virus propagation sites in the immunosuppressed macaques were larger than those in lungs of the immunocompetent macaques when they were infected with the pandemic virus. Immunosuppressed macaques possessed low levels of immune cells producing cytokines and chemokines, but levels of inflammatory cytokines/chemokine interleukin (IL)-6, IL-18, and monocyte chemotactic protein (MCP)-1 in lungs of the immunosuppressed macaques were higher than those in lungs of the immunocompetent macaques, though the differences were not statistically significant. Therefore, under an immunosuppressive condition, the pandemic influenza (H1N1) 2009 virus might cause more severe morbidity with high cytokine/chemokine production by the host innate immune system than that seen in macaques under the immunocompetent condition. |
| format |
article |
| author |
Van Loi Pham Misako Nakayama Yasushi Itoh Hirohito Ishigaki Mitsutaka Kitano Masahiko Arikata Hideaki Ishida Naoko Kitagawa Shintaro Shichinohe Masatoshi Okamatsu Yoshihiro Sakoda Hideaki Tsuchiya Shinichiro Nakamura Hiroshi Kida Kazumasa Ogasawara |
| author_facet |
Van Loi Pham Misako Nakayama Yasushi Itoh Hirohito Ishigaki Mitsutaka Kitano Masahiko Arikata Hideaki Ishida Naoko Kitagawa Shintaro Shichinohe Masatoshi Okamatsu Yoshihiro Sakoda Hideaki Tsuchiya Shinichiro Nakamura Hiroshi Kida Kazumasa Ogasawara |
| author_sort |
Van Loi Pham |
| title |
Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. |
| title_short |
Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. |
| title_full |
Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. |
| title_fullStr |
Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. |
| title_full_unstemmed |
Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. |
| title_sort |
pathogenicity of pandemic h1n1 influenza a virus in immunocompromised cynomolgus macaques. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/fe7c12e73f794def8635ea8987099fdb |
| work_keys_str_mv |
AT vanloipham pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT misakonakayama pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT yasushiitoh pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT hirohitoishigaki pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT mitsutakakitano pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT masahikoarikata pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT hideakiishida pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT naokokitagawa pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT shintaroshichinohe pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT masatoshiokamatsu pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT yoshihirosakoda pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT hideakitsuchiya pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT shinichironakamura pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT hiroshikida pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques AT kazumasaogasawara pathogenicityofpandemich1n1influenzaavirusinimmunocompromisedcynomolgusmacaques |
| _version_ |
1718421241930448896 |