An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells

Modelling gene expression and proliferation dynamics of pluripotent stem cells Mouse embryonic stem cells (mESCs) are pluripotent cells, having the potential to turn into most other cell types. A team led by Lucia Marucci at the University of Bristol, and involving collaborators from the University...

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Autores principales:	Simon Godwin, Daniel Ward, Elisa Pedone, Martin Homer, Alexander G. Fletcher, Lucia Marucci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fe7d280fe2fc44c489dde0d578fcc759
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spelling	oai:doaj.org-article:fe7d280fe2fc44c489dde0d578fcc7592021-12-02T16:09:11ZAn extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells10.1038/s41540-017-0020-52056-7189https://doaj.org/article/fe7d280fe2fc44c489dde0d578fcc7592017-08-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0020-5https://doaj.org/toc/2056-7189Modelling gene expression and proliferation dynamics of pluripotent stem cells Mouse embryonic stem cells (mESCs) are pluripotent cells, having the potential to turn into most other cell types. A team led by Lucia Marucci at the University of Bristol, and involving collaborators from the University of Sheffield, developed mathematical models to describe temporal dynamics of pluripotency genes in mESCs under different culture conditions. The team shows that the combination of feedback loops in the underlying gene regulatory networks, noise, and culture conditions fine-tunes gene expression dynamics and, consequently, the fate of mESCs. Experimental and modelling results highlight the interplay between pluripotency gene dynamics and cellular proliferation. Understanding the dynamical mechanisms that influence the fate of mESCs could guide the optimisation of culture protocols in both pluripotency and differentiation.Simon GodwinDaniel WardElisa PedoneMartin HomerAlexander G. FletcherLucia MarucciNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Simon Godwin Daniel Ward Elisa Pedone Martin Homer Alexander G. Fletcher Lucia Marucci An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
description	Modelling gene expression and proliferation dynamics of pluripotent stem cells Mouse embryonic stem cells (mESCs) are pluripotent cells, having the potential to turn into most other cell types. A team led by Lucia Marucci at the University of Bristol, and involving collaborators from the University of Sheffield, developed mathematical models to describe temporal dynamics of pluripotency genes in mESCs under different culture conditions. The team shows that the combination of feedback loops in the underlying gene regulatory networks, noise, and culture conditions fine-tunes gene expression dynamics and, consequently, the fate of mESCs. Experimental and modelling results highlight the interplay between pluripotency gene dynamics and cellular proliferation. Understanding the dynamical mechanisms that influence the fate of mESCs could guide the optimisation of culture protocols in both pluripotency and differentiation.
format	article
author	Simon Godwin Daniel Ward Elisa Pedone Martin Homer Alexander G. Fletcher Lucia Marucci
author_facet	Simon Godwin Daniel Ward Elisa Pedone Martin Homer Alexander G. Fletcher Lucia Marucci
author_sort	Simon Godwin
title	An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
title_short	An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
title_full	An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
title_fullStr	An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
title_full_unstemmed	An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
title_sort	extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fe7d280fe2fc44c489dde0d578fcc759
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An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells

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