Pharmacokinetics of ciprofloxacin in layer chicks
Pharmacokinetics parameters of ciprofloxacin were calculated from constructed plasma disappearing curves (PDC) after oral or i.v. injection of 5mg / kg in two-week old hybird layer · The i.v. PDC indicated a first order biphasic kinetic. The distribution phase was too short to be considered. The pa...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
University of Baghdad, College of Veterinary Medicine
1999
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/fe7ef8c317f64dd9a6a775a62d9063ea |
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| Sumario: | Pharmacokinetics parameters of ciprofloxacin were calculated from constructed plasma disappearing curves (PDC) after oral or i.v. injection of 5mg / kg in two-week old hybird layer · The i.v. PDC indicated a first order biphasic kinetic. The distribution phase was too short to be considered. The parameters of the elimination phase phase indicated that the biological half – life ( t 12) was 3.7 hours and the volume of distribution (Vd) was 1.7 1/kg.
The oral PDC indicated a first order kinetic with a peak plasma level (PPL) of 3.0 ug/ml achieved after 1.75 hours , a t 12 of 2.9 hours and a Vd of 1.7 1/kg . Bioavailability value was 84 +9.7% . Binding of ciprofloxacin to chicken plasma protein was estimated to be 25.4 61.3%.
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