Pharmacokinetics of ciprofloxacin in layer chicks

Pharmacokinetics parameters of ciprofloxacin were calculated from constructed plasma disappearing curves (PDC) after oral or i.v. injection of 5mg / kg in two-week old hybird layer · The i.v. PDC indicated a first order biphasic kinetic. The distribution phase was too short to be considered. The pa...

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Autores principales:	B. S. AI – Khafaji, A. A. Al-Khayyat, O.M.S. Al-Shaha
Formato:	article
Lenguaje:	EN
Publicado:	University of Baghdad, College of Veterinary Medicine 1999
Materias:	layer chicks ciprofloxacin Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/fe7ef8c317f64dd9a6a775a62d9063ea
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spelling	oai:doaj.org-article:fe7ef8c317f64dd9a6a775a62d9063ea2021-11-15T12:02:29ZPharmacokinetics of ciprofloxacin in layer chicks10.30539/ijvm.v23i1.11991609-56932410-7409https://doaj.org/article/fe7ef8c317f64dd9a6a775a62d9063ea1999-06-01T00:00:00Zhttps://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/1199https://doaj.org/toc/1609-5693https://doaj.org/toc/2410-7409 Pharmacokinetics parameters of ciprofloxacin were calculated from constructed plasma disappearing curves (PDC) after oral or i.v. injection of 5mg / kg in two-week old hybird layer · The i.v. PDC indicated a first order biphasic kinetic. The distribution phase was too short to be considered. The parameters of the elimination phase phase indicated that the biological half – life ( t 12) was 3.7 hours and the volume of distribution (Vd) was 1.7 1/kg. The oral PDC indicated a first order kinetic with a peak plasma level (PPL) of 3.0 ug/ml achieved after 1.75 hours , a t 12 of 2.9 hours and a Vd of 1.7 1/kg . Bioavailability value was 84 +9.7% . Binding of ciprofloxacin to chicken plasma protein was estimated to be 25.4 61.3%. B. S. AI – KhafajiA. A. Al-KhayyatO.M.S. Al-ShahaUniversity of Baghdad, College of Veterinary Medicinearticlelayer chicksciprofloxacinVeterinary medicineSF600-1100ENThe Iraqi Journal of Veterinary Medicine, Vol 23, Iss 1 (1999)
institution	DOAJ
collection	DOAJ
language	EN
topic	layer chicks ciprofloxacin Veterinary medicine SF600-1100
spellingShingle	layer chicks ciprofloxacin Veterinary medicine SF600-1100 B. S. AI – Khafaji A. A. Al-Khayyat O.M.S. Al-Shaha Pharmacokinetics of ciprofloxacin in layer chicks
description	Pharmacokinetics parameters of ciprofloxacin were calculated from constructed plasma disappearing curves (PDC) after oral or i.v. injection of 5mg / kg in two-week old hybird layer · The i.v. PDC indicated a first order biphasic kinetic. The distribution phase was too short to be considered. The parameters of the elimination phase phase indicated that the biological half – life ( t 12) was 3.7 hours and the volume of distribution (Vd) was 1.7 1/kg. The oral PDC indicated a first order kinetic with a peak plasma level (PPL) of 3.0 ug/ml achieved after 1.75 hours , a t 12 of 2.9 hours and a Vd of 1.7 1/kg . Bioavailability value was 84 +9.7% . Binding of ciprofloxacin to chicken plasma protein was estimated to be 25.4 61.3%.
format	article
author	B. S. AI – Khafaji A. A. Al-Khayyat O.M.S. Al-Shaha
author_facet	B. S. AI – Khafaji A. A. Al-Khayyat O.M.S. Al-Shaha
author_sort	B. S. AI – Khafaji
title	Pharmacokinetics of ciprofloxacin in layer chicks
title_short	Pharmacokinetics of ciprofloxacin in layer chicks
title_full	Pharmacokinetics of ciprofloxacin in layer chicks
title_fullStr	Pharmacokinetics of ciprofloxacin in layer chicks
title_full_unstemmed	Pharmacokinetics of ciprofloxacin in layer chicks
title_sort	pharmacokinetics of ciprofloxacin in layer chicks
publisher	University of Baghdad, College of Veterinary Medicine
publishDate	1999
url	https://doaj.org/article/fe7ef8c317f64dd9a6a775a62d9063ea
work_keys_str_mv	AT bsaikhafaji pharmacokineticsofciprofloxacininlayerchicks AT aaalkhayyat pharmacokineticsofciprofloxacininlayerchicks AT omsalshaha pharmacokineticsofciprofloxacininlayerchicks
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Pharmacokinetics of ciprofloxacin in layer chicks

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