POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression

RNA polymerase II subunit A (POLR2A) is the largest subunit encoding RNA polymerase II and closely related to cancer progression. However, the biological role and underlying molecular mechanism of POLR2A in gastric cancer (GC) are still unclear. Our study demonstrated that POLR2A was highly expresse...

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Autores principales:	Qiuyu Jiang, Jinyuan Zhang, Fang Li, Xiaoping Ma, Fei Wu, Jiyu Miao, Qian Li, Xiaofei Wang, Ruifang Sun, Yang Yang, Lingyu Zhao, Chen Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PolR2a gastric cancer transcriptional regulation cell cycle oncogene Genetics QH426-470
Acceso en línea:	https://doaj.org/article/fe80777accb44e51ab0da48b672127e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:fe80777accb44e51ab0da48b672127e42021-12-01T01:16:45ZPOLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression1664-802110.3389/fgene.2021.688575https://doaj.org/article/fe80777accb44e51ab0da48b672127e42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.688575/fullhttps://doaj.org/toc/1664-8021RNA polymerase II subunit A (POLR2A) is the largest subunit encoding RNA polymerase II and closely related to cancer progression. However, the biological role and underlying molecular mechanism of POLR2A in gastric cancer (GC) are still unclear. Our study demonstrated that POLR2A was highly expressed in GC tissue and promoted the proliferation of GC in vitro and in vivo. We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases (CDKs) at each stage and promoted their expression, indicated POLR2A’s overall promotion of cell cycle progression. Moreover, POLR2A inhibited GC cell apoptosis and promoted GC cell migration. Our results indicate that POLR2A play an oncogene role in GC, which may be an important factor involved in the occurrence and development of GC.Qiuyu JiangJinyuan ZhangFang LiXiaoping MaFei WuJiyu MiaoQian LiXiaofei WangRuifang SunYang YangLingyu ZhaoChen HuangFrontiers Media S.A.articlePolR2agastric cancertranscriptional regulationcell cycleoncogeneGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PolR2a gastric cancer transcriptional regulation cell cycle oncogene Genetics QH426-470
spellingShingle	PolR2a gastric cancer transcriptional regulation cell cycle oncogene Genetics QH426-470 Qiuyu Jiang Jinyuan Zhang Fang Li Xiaoping Ma Fei Wu Jiyu Miao Qian Li Xiaofei Wang Ruifang Sun Yang Yang Lingyu Zhao Chen Huang POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression
description	RNA polymerase II subunit A (POLR2A) is the largest subunit encoding RNA polymerase II and closely related to cancer progression. However, the biological role and underlying molecular mechanism of POLR2A in gastric cancer (GC) are still unclear. Our study demonstrated that POLR2A was highly expressed in GC tissue and promoted the proliferation of GC in vitro and in vivo. We also found that POLR2A participated in the transcriptional regulation of cyclins and cyclin-dependent kinases (CDKs) at each stage and promoted their expression, indicated POLR2A’s overall promotion of cell cycle progression. Moreover, POLR2A inhibited GC cell apoptosis and promoted GC cell migration. Our results indicate that POLR2A play an oncogene role in GC, which may be an important factor involved in the occurrence and development of GC.
format	article
author	Qiuyu Jiang Jinyuan Zhang Fang Li Xiaoping Ma Fei Wu Jiyu Miao Qian Li Xiaofei Wang Ruifang Sun Yang Yang Lingyu Zhao Chen Huang
author_facet	Qiuyu Jiang Jinyuan Zhang Fang Li Xiaoping Ma Fei Wu Jiyu Miao Qian Li Xiaofei Wang Ruifang Sun Yang Yang Lingyu Zhao Chen Huang
author_sort	Qiuyu Jiang
title	POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression
title_short	POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression
title_full	POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression
title_fullStr	POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression
title_full_unstemmed	POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression
title_sort	polr2a promotes the proliferation of gastric cancer cells by advancing the overall cell cycle progression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fe80777accb44e51ab0da48b672127e4
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POLR2A Promotes the Proliferation of Gastric Cancer Cells by Advancing the Overall Cell Cycle Progression

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