Dissecting the Human Response to Staphylococcus aureus Systemic Infections
Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:fe8237904efe4d4a82fcde3c3235b5672021-11-08T12:11:50ZDissecting the Human Response to Staphylococcus aureus Systemic Infections1664-322410.3389/fimmu.2021.749432https://doaj.org/article/fe8237904efe4d4a82fcde3c3235b5672021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.749432/fullhttps://doaj.org/toc/1664-3224Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors. We analyzed the inflammatory responses founding a pattern of distinctive cytokines significantly higher in the patients with invasive disease. The measure of antibody levels revealed a wide antibody responsiveness from all subjects to most of the antigens, with significantly higher response for some antigens in the invasive patients compared to control. Moreover, functional antibodies against toxins distinctively associated with the invasive disease. Finally, we examined the genomic variability of isolates, showing no major differences in genetic distribution compared to a panel of representative strains. Overall, our study shows specific signatures of cytokines and functional antibodies in patients with different primary invasive diseases caused by S. aureus. These data provide insight into human responses towards invasive staphylococcal infections and are important for guiding the identification of novel preventive and therapeutic interventions against S. aureus.Rosanna LeuzziMargherita BodiniIsaac P. ThomsenElisabetta SoldainiErika BartoliniAlessandro MuzziBruna ClementeBruno GallettiAndrea Guido Oreste ManettiCinzia GiovaniStefano CensiniSonia BudroniFabiana SpensieriErica BorgogniSilvia Rossi PaccaniImmaculada MargaritFabio BagnoliGiuseppe Del GiudiceClarence B. CreechFrontiers Media S.A.articleStaphylococcus aureusinvasiveantibodycytokinesisolatesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
Staphylococcus aureus invasive antibody cytokines isolates Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
Staphylococcus aureus invasive antibody cytokines isolates Immunologic diseases. Allergy RC581-607 Rosanna Leuzzi Margherita Bodini Isaac P. Thomsen Elisabetta Soldaini Erika Bartolini Alessandro Muzzi Bruna Clemente Bruno Galletti Andrea Guido Oreste Manetti Cinzia Giovani Stefano Censini Sonia Budroni Fabiana Spensieri Erica Borgogni Silvia Rossi Paccani Immaculada Margarit Fabio Bagnoli Giuseppe Del Giudice Clarence B. Creech Dissecting the Human Response to Staphylococcus aureus Systemic Infections |
| description |
Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors. We analyzed the inflammatory responses founding a pattern of distinctive cytokines significantly higher in the patients with invasive disease. The measure of antibody levels revealed a wide antibody responsiveness from all subjects to most of the antigens, with significantly higher response for some antigens in the invasive patients compared to control. Moreover, functional antibodies against toxins distinctively associated with the invasive disease. Finally, we examined the genomic variability of isolates, showing no major differences in genetic distribution compared to a panel of representative strains. Overall, our study shows specific signatures of cytokines and functional antibodies in patients with different primary invasive diseases caused by S. aureus. These data provide insight into human responses towards invasive staphylococcal infections and are important for guiding the identification of novel preventive and therapeutic interventions against S. aureus. |
| format |
article |
| author |
Rosanna Leuzzi Margherita Bodini Isaac P. Thomsen Elisabetta Soldaini Erika Bartolini Alessandro Muzzi Bruna Clemente Bruno Galletti Andrea Guido Oreste Manetti Cinzia Giovani Stefano Censini Sonia Budroni Fabiana Spensieri Erica Borgogni Silvia Rossi Paccani Immaculada Margarit Fabio Bagnoli Giuseppe Del Giudice Clarence B. Creech |
| author_facet |
Rosanna Leuzzi Margherita Bodini Isaac P. Thomsen Elisabetta Soldaini Erika Bartolini Alessandro Muzzi Bruna Clemente Bruno Galletti Andrea Guido Oreste Manetti Cinzia Giovani Stefano Censini Sonia Budroni Fabiana Spensieri Erica Borgogni Silvia Rossi Paccani Immaculada Margarit Fabio Bagnoli Giuseppe Del Giudice Clarence B. Creech |
| author_sort |
Rosanna Leuzzi |
| title |
Dissecting the Human Response to Staphylococcus aureus Systemic Infections |
| title_short |
Dissecting the Human Response to Staphylococcus aureus Systemic Infections |
| title_full |
Dissecting the Human Response to Staphylococcus aureus Systemic Infections |
| title_fullStr |
Dissecting the Human Response to Staphylococcus aureus Systemic Infections |
| title_full_unstemmed |
Dissecting the Human Response to Staphylococcus aureus Systemic Infections |
| title_sort |
dissecting the human response to staphylococcus aureus systemic infections |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/fe8237904efe4d4a82fcde3c3235b567 |
| work_keys_str_mv |
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