Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery

Bret L Fisher,1 Rick Potvin2 1Eye Center of North Florida, Panama City, FL, USA; 2Science in Vision, Akron, NY, USA Purpose: To compare the relative effectiveness of a Tri-Moxi-Vanc intraocular solution injected transzonularly into the vitreous with the topical formulation of Pred-Moxi-Ketor (give...

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Autores principales:	Fisher BL, Potvin R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Prophylaxis phacoemulsification intracameral antibiotics steroids cataract surgery Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fe857fcd96ad4e1bb6013f953635a39a
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spelling	oai:doaj.org-article:fe857fcd96ad4e1bb6013f953635a39a2021-12-02T06:22:40ZTranszonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery1177-5483https://doaj.org/article/fe857fcd96ad4e1bb6013f953635a39a2016-07-01T00:00:00Zhttps://www.dovepress.com/transzonular-vitreous-injection-vs-a-single-drop-compounded-topical-ph-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Bret L Fisher,1 Rick Potvin2 1Eye Center of North Florida, Panama City, FL, USA; 2Science in Vision, Akron, NY, USA Purpose: To compare the relative effectiveness of a Tri-Moxi-Vanc intraocular solution injected transzonularly into the vitreous with the topical formulation of Pred-Moxi-Ketor (given for the first week postoperatively) followed by Pred-Ketor (given for weeks 2–4 after surgery). Patients and methods: This was a single-site, single-surgeon, prospective, randomized, subject-masked contralateral eye study with an active comparator and was approved by an appropriate ethics committee. Twenty-five subjects with uncomplicated cataract who were scheduled for cataract surgery were enrolled. If surgery was uneventful, subjects received either an injection in that eye or followed a minimum drop postoperative pharmaceutical regimen. The second eye surgery was performed with the opposite treatment. Subjects were followed for 1 month. Measures of interest were the changes in intraocular pressure (IOP) from baseline and the changes in corneal and macular thickness. Subjects were also asked to evaluate pain perception, visual quality, and overall satisfaction with surgery. They were also asked which regimen they preferred. Results: IOP was not statistically significantly different between the groups (P=0.81); there was also no statistically significant difference in IOP over time (P=0.74). There was no statistically significant difference in central macular thickness at 1 week and 1 month between the groups (P=0.18). The central corneal thickness was significantly greater 1 day postoperatively relative to baseline, but there was no statistically significant difference between the groups at any time point (P=0.92). The difference in reported pain was also not statistically significantly different between the groups (P=0.67). Satisfaction with surgery was similar for both groups, but significantly more subjects preferred the injection for overall experience (P<0.01). Conclusion: Cataract surgery completed with the two pharmaceutical regimens was similar in outcome. Significantly more subjects preferred the injection, presumably as a function of the greater convenience with no apparent difference in the therapeutic effect. Keywords: prophylaxis, phacoemulsification, intracameral, antibiotics, steroids, cataract surgeryFisher BLPotvin RDove Medical PressarticleProphylaxisphacoemulsificationintracameralantibioticssteroidscataract surgeryOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1297-1303 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prophylaxis phacoemulsification intracameral antibiotics steroids cataract surgery Ophthalmology RE1-994
spellingShingle	Prophylaxis phacoemulsification intracameral antibiotics steroids cataract surgery Ophthalmology RE1-994 Fisher BL Potvin R Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
description	Bret L Fisher,1 Rick Potvin2 1Eye Center of North Florida, Panama City, FL, USA; 2Science in Vision, Akron, NY, USA Purpose: To compare the relative effectiveness of a Tri-Moxi-Vanc intraocular solution injected transzonularly into the vitreous with the topical formulation of Pred-Moxi-Ketor (given for the first week postoperatively) followed by Pred-Ketor (given for weeks 2–4 after surgery). Patients and methods: This was a single-site, single-surgeon, prospective, randomized, subject-masked contralateral eye study with an active comparator and was approved by an appropriate ethics committee. Twenty-five subjects with uncomplicated cataract who were scheduled for cataract surgery were enrolled. If surgery was uneventful, subjects received either an injection in that eye or followed a minimum drop postoperative pharmaceutical regimen. The second eye surgery was performed with the opposite treatment. Subjects were followed for 1 month. Measures of interest were the changes in intraocular pressure (IOP) from baseline and the changes in corneal and macular thickness. Subjects were also asked to evaluate pain perception, visual quality, and overall satisfaction with surgery. They were also asked which regimen they preferred. Results: IOP was not statistically significantly different between the groups (P=0.81); there was also no statistically significant difference in IOP over time (P=0.74). There was no statistically significant difference in central macular thickness at 1 week and 1 month between the groups (P=0.18). The central corneal thickness was significantly greater 1 day postoperatively relative to baseline, but there was no statistically significant difference between the groups at any time point (P=0.92). The difference in reported pain was also not statistically significantly different between the groups (P=0.67). Satisfaction with surgery was similar for both groups, but significantly more subjects preferred the injection for overall experience (P<0.01). Conclusion: Cataract surgery completed with the two pharmaceutical regimens was similar in outcome. Significantly more subjects preferred the injection, presumably as a function of the greater convenience with no apparent difference in the therapeutic effect. Keywords: prophylaxis, phacoemulsification, intracameral, antibiotics, steroids, cataract surgery
format	article
author	Fisher BL Potvin R
author_facet	Fisher BL Potvin R
author_sort	Fisher BL
title	Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
title_short	Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
title_full	Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
title_fullStr	Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
title_full_unstemmed	Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
title_sort	transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/fe857fcd96ad4e1bb6013f953635a39a
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Transzonular vitreous injection vs a single drop compounded topical pharmaceutical regimen after cataract surgery

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