Asymmetric biomimetic transamination of α-keto amides to peptides

Asymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α-keto amides, providing access to various peptide...

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Autores principales:	Weiqi Cai, Xuelong Qiao, Hao Zhang, Bo Li, Jianhua Guo, Liangliang Zhang, Wen-Wen Chen, Baoguo Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe90a4183f1e4373aaebb49c05c7f719
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spelling	oai:doaj.org-article:fe90a4183f1e4373aaebb49c05c7f7192021-12-02T19:04:01ZAsymmetric biomimetic transamination of α-keto amides to peptides10.1038/s41467-021-25449-y2041-1723https://doaj.org/article/fe90a4183f1e4373aaebb49c05c7f7192021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25449-yhttps://doaj.org/toc/2041-1723Asymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α-keto amides, providing access to various peptides with excellent enantiopurities.Weiqi CaiXuelong QiaoHao ZhangBo LiJianhua GuoLiangliang ZhangWen-Wen ChenBaoguo ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiqi Cai Xuelong Qiao Hao Zhang Bo Li Jianhua Guo Liangliang Zhang Wen-Wen Chen Baoguo Zhao Asymmetric biomimetic transamination of α-keto amides to peptides
description	Asymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α-keto amides, providing access to various peptides with excellent enantiopurities.
format	article
author	Weiqi Cai Xuelong Qiao Hao Zhang Bo Li Jianhua Guo Liangliang Zhang Wen-Wen Chen Baoguo Zhao
author_facet	Weiqi Cai Xuelong Qiao Hao Zhang Bo Li Jianhua Guo Liangliang Zhang Wen-Wen Chen Baoguo Zhao
author_sort	Weiqi Cai
title	Asymmetric biomimetic transamination of α-keto amides to peptides
title_short	Asymmetric biomimetic transamination of α-keto amides to peptides
title_full	Asymmetric biomimetic transamination of α-keto amides to peptides
title_fullStr	Asymmetric biomimetic transamination of α-keto amides to peptides
title_full_unstemmed	Asymmetric biomimetic transamination of α-keto amides to peptides
title_sort	asymmetric biomimetic transamination of α-keto amides to peptides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fe90a4183f1e4373aaebb49c05c7f719
work_keys_str_mv	AT weiqicai asymmetricbiomimetictransaminationofaketoamidestopeptides AT xuelongqiao asymmetricbiomimetictransaminationofaketoamidestopeptides AT haozhang asymmetricbiomimetictransaminationofaketoamidestopeptides AT boli asymmetricbiomimetictransaminationofaketoamidestopeptides AT jianhuaguo asymmetricbiomimetictransaminationofaketoamidestopeptides AT liangliangzhang asymmetricbiomimetictransaminationofaketoamidestopeptides AT wenwenchen asymmetricbiomimetictransaminationofaketoamidestopeptides AT baoguozhao asymmetricbiomimetictransaminationofaketoamidestopeptides
_version_	1718377246079582208

Asymmetric biomimetic transamination of α-keto amides to peptides

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