Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to intensive research, important steps in the elucidation of pathogenetic cascades have been made and significantly implicated mitochondrial dysfunction and oxidative stress. However, the available treatment in Al...

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Autor principal:	Anamaria Jurcau
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondrial dysfunction oxidative stress antioxidants Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fe91177569bf4c21b03f09446a56db96
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spelling	oai:doaj.org-article:fe91177569bf4c21b03f09446a56db962021-11-11T17:16:30ZInsights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress10.3390/ijms2221118471422-00671661-6596https://doaj.org/article/fe91177569bf4c21b03f09446a56db962021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11847https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067As the population ages, the incidence of neurodegenerative diseases is increasing. Due to intensive research, important steps in the elucidation of pathogenetic cascades have been made and significantly implicated mitochondrial dysfunction and oxidative stress. However, the available treatment in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis is mainly symptomatic, providing minor benefits and, at most, slowing down the progression of the disease. Although in preclinical setting, drugs targeting mitochondrial dysfunction and oxidative stress yielded encouraging results, clinical trials failed or had inconclusive results. It is likely that by the time of clinical diagnosis, the pathogenetic cascades are full-blown and significant numbers of neurons have already degenerated, making it impossible for mitochondria-targeted or antioxidant molecules to stop or reverse the process. Until further research will provide more efficient molecules, a healthy lifestyle, with plenty of dietary antioxidants and avoidance of exogenous oxidants may postpone the onset of neurodegeneration, while familial cases may benefit from genetic testing and aggressive therapy started in the preclinical stage.Anamaria JurcauMDPI AGarticlemitochondrial dysfunctionoxidative stressantioxidantsAlzheimer’s diseaseParkinson’s diseaseamyotrophic lateral sclerosisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11847, p 11847 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondrial dysfunction oxidative stress antioxidants Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mitochondrial dysfunction oxidative stress antioxidants Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis Biology (General) QH301-705.5 Chemistry QD1-999 Anamaria Jurcau Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
description	As the population ages, the incidence of neurodegenerative diseases is increasing. Due to intensive research, important steps in the elucidation of pathogenetic cascades have been made and significantly implicated mitochondrial dysfunction and oxidative stress. However, the available treatment in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis is mainly symptomatic, providing minor benefits and, at most, slowing down the progression of the disease. Although in preclinical setting, drugs targeting mitochondrial dysfunction and oxidative stress yielded encouraging results, clinical trials failed or had inconclusive results. It is likely that by the time of clinical diagnosis, the pathogenetic cascades are full-blown and significant numbers of neurons have already degenerated, making it impossible for mitochondria-targeted or antioxidant molecules to stop or reverse the process. Until further research will provide more efficient molecules, a healthy lifestyle, with plenty of dietary antioxidants and avoidance of exogenous oxidants may postpone the onset of neurodegeneration, while familial cases may benefit from genetic testing and aggressive therapy started in the preclinical stage.
format	article
author	Anamaria Jurcau
author_facet	Anamaria Jurcau
author_sort	Anamaria Jurcau
title	Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
title_short	Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
title_full	Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
title_fullStr	Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
title_full_unstemmed	Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress
title_sort	insights into the pathogenesis of neurodegenerative diseases: focus on mitochondrial dysfunction and oxidative stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fe91177569bf4c21b03f09446a56db96
work_keys_str_mv	AT anamariajurcau insightsintothepathogenesisofneurodegenerativediseasesfocusonmitochondrialdysfunctionandoxidativestress
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Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

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