Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study

Abstract Children with brain tumors (CBT) are at higher risk of cardiovascular disease and type 2 diabetes compared to the general population, in which birth weight is a risk factor for these diseases. However, this is not known in CBT. The primary aim of this study was to explore the association be...

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Autores principales:	Kuan-Wen Wang, Russell J. de Souza, Adam Fleming, Donna L. Johnston, Shayna M. Zelcer, Shahrad Rod Rassekh, Sarah Burrow, Lehana Thabane, M. Constantine Samaan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fe91679aaf0d470f9e55db4385badbf6
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spelling	oai:doaj.org-article:fe91679aaf0d470f9e55db4385badbf62021-12-02T15:08:03ZBirth weight and body mass index z-score in childhood brain tumors: A cross-sectional study10.1038/s41598-018-19924-82045-2322https://doaj.org/article/fe91679aaf0d470f9e55db4385badbf62018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19924-8https://doaj.org/toc/2045-2322Abstract Children with brain tumors (CBT) are at higher risk of cardiovascular disease and type 2 diabetes compared to the general population, in which birth weight is a risk factor for these diseases. However, this is not known in CBT. The primary aim of this study was to explore the association between birth weight and body mass measures in CBT, compared to non-cancer controls. This is a secondary data analysis using cross-sectional data from the CanDECIDE study (n = 78 CBT and n = 133 non-cancer controls). Age, sex, and birth weight (grams) were self-reported, and confirmed through examination of the medical records. Body mass index (BMI) was calculated from height and weight measures and reported as kg/m2. BMI z-scores were obtained for subjects under the age of 20 years. Multivariable linear regression was used to evaluate the relationship between birth weight and BMI and BMI z-score, adjusted for age, sex, puberty, and fat mass percentage. Higher birth weight was associated with higher BMI and BMI z-score among CBT and controls. In conclusion, birth weight is a risk factor for higher body mass during childhood in CBT, and this may help the identification of children at risk of future obesity and cardiometabolic risk.Kuan-Wen WangRussell J. de SouzaAdam FlemingDonna L. JohnstonShayna M. ZelcerShahrad Rod RassekhSarah BurrowLehana ThabaneM. Constantine SamaanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuan-Wen Wang Russell J. de Souza Adam Fleming Donna L. Johnston Shayna M. Zelcer Shahrad Rod Rassekh Sarah Burrow Lehana Thabane M. Constantine Samaan Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study
description	Abstract Children with brain tumors (CBT) are at higher risk of cardiovascular disease and type 2 diabetes compared to the general population, in which birth weight is a risk factor for these diseases. However, this is not known in CBT. The primary aim of this study was to explore the association between birth weight and body mass measures in CBT, compared to non-cancer controls. This is a secondary data analysis using cross-sectional data from the CanDECIDE study (n = 78 CBT and n = 133 non-cancer controls). Age, sex, and birth weight (grams) were self-reported, and confirmed through examination of the medical records. Body mass index (BMI) was calculated from height and weight measures and reported as kg/m2. BMI z-scores were obtained for subjects under the age of 20 years. Multivariable linear regression was used to evaluate the relationship between birth weight and BMI and BMI z-score, adjusted for age, sex, puberty, and fat mass percentage. Higher birth weight was associated with higher BMI and BMI z-score among CBT and controls. In conclusion, birth weight is a risk factor for higher body mass during childhood in CBT, and this may help the identification of children at risk of future obesity and cardiometabolic risk.
format	article
author	Kuan-Wen Wang Russell J. de Souza Adam Fleming Donna L. Johnston Shayna M. Zelcer Shahrad Rod Rassekh Sarah Burrow Lehana Thabane M. Constantine Samaan
author_facet	Kuan-Wen Wang Russell J. de Souza Adam Fleming Donna L. Johnston Shayna M. Zelcer Shahrad Rod Rassekh Sarah Burrow Lehana Thabane M. Constantine Samaan
author_sort	Kuan-Wen Wang
title	Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study
title_short	Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study
title_full	Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study
title_fullStr	Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study
title_full_unstemmed	Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study
title_sort	birth weight and body mass index z-score in childhood brain tumors: a cross-sectional study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fe91679aaf0d470f9e55db4385badbf6
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Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study

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