Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylation of the CMA receptor LAMP2A by the lysosomal p38...

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Autores principales:	Wenming Li, Jinqiu Zhu, Juan Dou, Hua She, Kai Tao, Haidong Xu, Qian Yang, Zixu Mao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe92931b0c6143268e9973c526173436
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spelling	oai:doaj.org-article:fe92931b0c6143268e9973c5261734362021-12-02T14:41:58ZPhosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy10.1038/s41467-017-01609-x2041-1723https://doaj.org/article/fe92931b0c6143268e9973c5261734362017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01609-xhttps://doaj.org/toc/2041-1723The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylation of the CMA receptor LAMP2A by the lysosomal p38 MAPK.Wenming LiJinqiu ZhuJuan DouHua SheKai TaoHaidong XuQian YangZixu MaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenming Li Jinqiu Zhu Juan Dou Hua She Kai Tao Haidong Xu Qian Yang Zixu Mao Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
description	The endoplasmic reticulum (ER) and lysosome are central to cellular stress responses, but it is unclear how ER stress is signaled to lysosomes. Here the authors show that ER stress activates chaperone-mediated autophagy (CMA) via direct phosphorylation of the CMA receptor LAMP2A by the lysosomal p38 MAPK.
format	article
author	Wenming Li Jinqiu Zhu Juan Dou Hua She Kai Tao Haidong Xu Qian Yang Zixu Mao
author_facet	Wenming Li Jinqiu Zhu Juan Dou Hua She Kai Tao Haidong Xu Qian Yang Zixu Mao
author_sort	Wenming Li
title	Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
title_short	Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
title_full	Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
title_fullStr	Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
title_full_unstemmed	Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy
title_sort	phosphorylation of lamp2a by p38 mapk couples er stress to chaperone-mediated autophagy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fe92931b0c6143268e9973c526173436
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Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy

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