Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivation ofMYC.

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Autores principales:	Steffen Grampp, James L. Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K. Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J. Ratcliffe, David R. Mole, Johannes Schödel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fe92f998e7f14012877889b0b60dd9cb
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spelling	oai:doaj.org-article:fe92f998e7f14012877889b0b60dd9cb2021-12-02T16:49:26ZGenetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer10.1038/ncomms131832041-1723https://doaj.org/article/fe92f998e7f14012877889b0b60dd9cb2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13183https://doaj.org/toc/2041-1723Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivation ofMYC.Steffen GramppJames L. PlattVictoria LauerRafik SalamaFranziska KranzViviana K. NeumannSven WachChristine StöhrArndt HartmannKai-Uwe EckardtPeter J. RatcliffeDavid R. MoleJohannes SchödelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steffen Grampp James L. Platt Victoria Lauer Rafik Salama Franziska Kranz Viviana K. Neumann Sven Wach Christine Stöhr Arndt Hartmann Kai-Uwe Eckardt Peter J. Ratcliffe David R. Mole Johannes Schödel Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
description	Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivation ofMYC.
format	article
author	Steffen Grampp James L. Platt Victoria Lauer Rafik Salama Franziska Kranz Viviana K. Neumann Sven Wach Christine Stöhr Arndt Hartmann Kai-Uwe Eckardt Peter J. Ratcliffe David R. Mole Johannes Schödel
author_facet	Steffen Grampp James L. Platt Victoria Lauer Rafik Salama Franziska Kranz Viviana K. Neumann Sven Wach Christine Stöhr Arndt Hartmann Kai-Uwe Eckardt Peter J. Ratcliffe David R. Mole Johannes Schödel
author_sort	Steffen Grampp
title	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
title_short	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
title_full	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
title_fullStr	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
title_full_unstemmed	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
title_sort	genetic variation at the 8q24.21 renal cancer susceptibility locus affects hif binding to a myc enhancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fe92f998e7f14012877889b0b60dd9cb
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Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

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