INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/fe9349e45d704ae08ac4398579ad9c21 |
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| Sumario: | Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,with amplified proliferative potential demonstrable in this group. We have also shown a trend to increasednumbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cellproliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectionalchanges of FasR expression were observed. However, the parameters reflecting readiness to apoptosis werechanged multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemiamay influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,causing an imbalance between cellular proliferation and apoptosis. |
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