INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA

Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients...

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Auteurs principaux:	A. V. Zurochka, E. V. Davydova, D. A. Altman
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	initial manifestation of insufficient blood supply to the brain dyslipidemia apoptosis cell proliferation Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/fe9349e45d704ae08ac4398579ad9c21
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spelling	oai:doaj.org-article:fe9349e45d704ae08ac4398579ad9c212021-11-18T08:03:37ZINTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA1563-06252313-741X10.15789/1563-0625-2014-1-27-34https://doaj.org/article/fe9349e45d704ae08ac4398579ad9c212014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/19https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIncidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,with amplified proliferative potential demonstrable in this group. We have also shown a trend to increasednumbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cellproliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectionalchanges of FasR expression were observed. However, the parameters reflecting readiness to apoptosis werechanged multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemiamay influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,causing an imbalance between cellular proliferation and apoptosis.A. V. ZurochkaE. V. DavydovaD. A. AltmanSPb RAACIarticleinitial manifestation of insufficient blood supply to the braindyslipidemiaapoptosiscell proliferationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 1, Pp 27-34 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	initial manifestation of insufficient blood supply to the brain dyslipidemia apoptosis cell proliferation Immunologic diseases. Allergy RC581-607
spellingShingle	initial manifestation of insufficient blood supply to the brain dyslipidemia apoptosis cell proliferation Immunologic diseases. Allergy RC581-607 A. V. Zurochka E. V. Davydova D. A. Altman INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
description	Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis andproliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flowinsufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,with amplified proliferative potential demonstrable in this group. We have also shown a trend to increasednumbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cellproliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectionalchanges of FasR expression were observed. However, the parameters reflecting readiness to apoptosis werechanged multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemiamay influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,causing an imbalance between cellular proliferation and apoptosis.
format	article
author	A. V. Zurochka E. V. Davydova D. A. Altman
author_facet	A. V. Zurochka E. V. Davydova D. A. Altman
author_sort	A. V. Zurochka
title	INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
title_short	INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
title_full	INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
title_fullStr	INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
title_full_unstemmed	INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
title_sort	intensity of apoptotic and proliferative events in lymphocytes under dyslipidemic conditions at early stages of chronic brain ischemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/fe9349e45d704ae08ac4398579ad9c21
work_keys_str_mv	AT avzurochka intensityofapoptoticandproliferativeeventsinlymphocytesunderdyslipidemicconditionsatearlystagesofchronicbrainischemia AT evdavydova intensityofapoptoticandproliferativeeventsinlymphocytesunderdyslipidemicconditionsatearlystagesofchronicbrainischemia AT daaltman intensityofapoptoticandproliferativeeventsinlymphocytesunderdyslipidemicconditionsatearlystagesofchronicbrainischemia
_version_	1718422583177641984

INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA

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