Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile

Monica Zolezzi,1 Rawan Abouelhassan,1 Yassin Eltorki,2 Peter M Haddad,2 Mahtab Noorizadeh1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Mental Health Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, Qatar University, PO Box 2713,...

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Autores principales:	Zolezzi M, Abouelhassan R, Eltorki Y, Haddad PM, Noorizadeh M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	intramuscular preparations depot antipsychotics injection site adverse effects Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fe95571e0823467983a83e86dafadb3d
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spelling	oai:doaj.org-article:fe95571e0823467983a83e86dafadb3d2021-12-02T17:44:01ZLong-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile1178-2021https://doaj.org/article/fe95571e0823467983a83e86dafadb3d2021-06-01T00:00:00Zhttps://www.dovepress.com/long-acting-injectable-antipsychotics-a-systematic-review-of-their-non-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Monica Zolezzi,1 Rawan Abouelhassan,1 Yassin Eltorki,2 Peter M Haddad,2 Mahtab Noorizadeh1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Mental Health Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, Qatar University, PO Box 2713, Doha, QatarEmail mzolezzi@qu.edu.qaIntroduction: Long acting injectable (LAI) antipsychotics are commonly used in the treatment of schizophrenia to improve adherence and clinical outcomes. Concerns have been reported in relation to their non-systemic or injection site adverse effect profile. As such, this study aims to review and evaluate all evidence reporting injection site adverse effects with LAI antipsychotics.Methods: An electronic search was systematically conducted through four databases (PubMed, Embase, SCOPUS, Cochrane) in order to identify studies investigating injection-site reactions associated with LAI antipsychotics. Unpublished studies such as conference proceedings and clinical trial registries were also searched. The search was limited to literature published in English without year limits.Results: Of a total of 189 citations that were identified from the electronic database search, 12 were selected for inclusion in this review. Various injection site reactions were reported in these studies, including pain, bleeding, and swelling. Overall, the studies reported a low incidence of these injection site reactions. Only a minority of the included articles compared injection site reactions between different LAI antipsychotics.Conclusion: Injection site pain was the most commonly reported injection site adverse effect across all articles reviewed. The low incidence of injection site adverse effects associated with LAI antipsychotics indicates that these formulations appear to be well tolerated by patients. More head-to-head trials comparing second generation LAI antipsychotics are needed.Keywords: intramuscular preparations, depot antipsychotics, injection site adverse effectsZolezzi MAbouelhassan REltorki YHaddad PMNoorizadeh MDove Medical Pressarticleintramuscular preparationsdepot antipsychoticsinjection site adverse effectsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1917-1926 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intramuscular preparations depot antipsychotics injection site adverse effects Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	intramuscular preparations depot antipsychotics injection site adverse effects Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zolezzi M Abouelhassan R Eltorki Y Haddad PM Noorizadeh M Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile
description	Monica Zolezzi,1 Rawan Abouelhassan,1 Yassin Eltorki,2 Peter M Haddad,2 Mahtab Noorizadeh1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Mental Health Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, Qatar University, PO Box 2713, Doha, QatarEmail mzolezzi@qu.edu.qaIntroduction: Long acting injectable (LAI) antipsychotics are commonly used in the treatment of schizophrenia to improve adherence and clinical outcomes. Concerns have been reported in relation to their non-systemic or injection site adverse effect profile. As such, this study aims to review and evaluate all evidence reporting injection site adverse effects with LAI antipsychotics.Methods: An electronic search was systematically conducted through four databases (PubMed, Embase, SCOPUS, Cochrane) in order to identify studies investigating injection-site reactions associated with LAI antipsychotics. Unpublished studies such as conference proceedings and clinical trial registries were also searched. The search was limited to literature published in English without year limits.Results: Of a total of 189 citations that were identified from the electronic database search, 12 were selected for inclusion in this review. Various injection site reactions were reported in these studies, including pain, bleeding, and swelling. Overall, the studies reported a low incidence of these injection site reactions. Only a minority of the included articles compared injection site reactions between different LAI antipsychotics.Conclusion: Injection site pain was the most commonly reported injection site adverse effect across all articles reviewed. The low incidence of injection site adverse effects associated with LAI antipsychotics indicates that these formulations appear to be well tolerated by patients. More head-to-head trials comparing second generation LAI antipsychotics are needed.Keywords: intramuscular preparations, depot antipsychotics, injection site adverse effects
format	article
author	Zolezzi M Abouelhassan R Eltorki Y Haddad PM Noorizadeh M
author_facet	Zolezzi M Abouelhassan R Eltorki Y Haddad PM Noorizadeh M
author_sort	Zolezzi M
title	Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile
title_short	Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile
title_full	Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile
title_fullStr	Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile
title_full_unstemmed	Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile
title_sort	long-acting injectable antipsychotics: a systematic review of their non-systemic adverse effect profile
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/fe95571e0823467983a83e86dafadb3d
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Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile

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