Sirt1 negatively regulates FcεRI-mediated mast cell activation through AMPK- and PTP1B-dependent processes

Abstract Sirt1, a key regulator of metabolism and longevity, has recently been implicated in the regulation of allergic reactions, although the underlying mechanism remains unclear. Here we show that Sirt1 negatively regulates FcεRI-stimulated mast cell activation and anaphylaxis through two mutuall...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xian Li, Youn Ju Lee, Fansi Jin, Young Na Park, Yifeng Deng, Youra Kang, Ju Hye Yang, Jae-Hoon Chang, Dong-Young Kim, Jung-Ae Kim, Young-Chae Chang, Hyun-Jeong Ko, Cheorl-Ho Kim, Makoto Murakami, Hyeun Wook Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
R
Q
Acceso en línea:https://doaj.org/article/fe97cadf8a3945a097993ecc828d856a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!