Role of Stem-Cell Transplantation in Leukemia Treatment

Gashaw Dessie,1 Meseret Derbew Molla,1 Tewodros Shibabaw,1 Birhanu Ayelign2 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Immunology and Molecular Biology, School of Biomedical and Laboratory, College...

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Autores principales:	Dessie G, Derbew Molla M, Shibabaw T, Ayelign B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	stem cell leukemia transplantation Cytology QH573-671
Acceso en línea:	https://doaj.org/article/fe997b6034ea485f8aa85ed211299be9
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spelling	oai:doaj.org-article:fe997b6034ea485f8aa85ed211299be92021-12-02T10:30:31ZRole of Stem-Cell Transplantation in Leukemia Treatment1178-6957https://doaj.org/article/fe997b6034ea485f8aa85ed211299be92020-08-01T00:00:00Zhttps://www.dovepress.com/role-of-stem-cell-transplantation-in-leukemia-treatment-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Gashaw Dessie,1 Meseret Derbew Molla,1 Tewodros Shibabaw,1 Birhanu Ayelign2 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Immunology and Molecular Biology, School of Biomedical and Laboratory, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Gashaw DessieDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaTel +251-97-515-2796Email dessiegashaw@yahoo.comAbstract: Stem cells (SCs) play a major role in advanced fields of regenerative medicine and other research areas. They are involved in the regeneration of damaged tissue or cells, due to their self-renewal characteristics. Tissue or cells can be damaged through a variety of diseases, including hematologic and nonhematologic malignancies. In regard to this, stem-cell transplantation is a cellular therapeutic approach to restore those impaired cells, tissue, or organs. SCs have a therapeutic potential in the application of stem-cell transplantation. Research has been focused mainly on the application of hematopoietic SCs for transplantation. Cord blood cells and human leukocyte antigen–haploidentical donors are considered optional sources of hematopoietic stem–cell transplantation. On the other hand, pluripotent embryonic SCs and induced pluripotent SCs hold promise for advancement of stem-cell transplantation. In addition, nonhematopoietic mesenchymal SCs play their own significant role as a functional bone-marrow niche and in the management of graft-vs-host disease effects during the posttransplantation process. In this review, the role of different types of SCs is presented with regard to their application in SC transplantation. In addition to this, the therapeutic value of autologous and allogeneic hematopoietic stem–cell transplantation is assessed with respect to different types of leukemia. Highly advanced and progressive scientific research has focused on the application of stem-cell transplantation on specific leukemia types. We evaluated and compared the therapeutic potential of SC transplantation with various forms of leukemia. This review aimed to focus on the application of SCs in the treatment of leukemia.Keywords: stem cell, leukemia, transplantationDessie GDerbew Molla MShibabaw TAyelign BDove Medical Pressarticlestem cellleukemiatransplantationCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 13, Pp 67-77 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell leukemia transplantation Cytology QH573-671
spellingShingle	stem cell leukemia transplantation Cytology QH573-671 Dessie G Derbew Molla M Shibabaw T Ayelign B Role of Stem-Cell Transplantation in Leukemia Treatment
description	Gashaw Dessie,1 Meseret Derbew Molla,1 Tewodros Shibabaw,1 Birhanu Ayelign2 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Immunology and Molecular Biology, School of Biomedical and Laboratory, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Gashaw DessieDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaTel +251-97-515-2796Email dessiegashaw@yahoo.comAbstract: Stem cells (SCs) play a major role in advanced fields of regenerative medicine and other research areas. They are involved in the regeneration of damaged tissue or cells, due to their self-renewal characteristics. Tissue or cells can be damaged through a variety of diseases, including hematologic and nonhematologic malignancies. In regard to this, stem-cell transplantation is a cellular therapeutic approach to restore those impaired cells, tissue, or organs. SCs have a therapeutic potential in the application of stem-cell transplantation. Research has been focused mainly on the application of hematopoietic SCs for transplantation. Cord blood cells and human leukocyte antigen–haploidentical donors are considered optional sources of hematopoietic stem–cell transplantation. On the other hand, pluripotent embryonic SCs and induced pluripotent SCs hold promise for advancement of stem-cell transplantation. In addition, nonhematopoietic mesenchymal SCs play their own significant role as a functional bone-marrow niche and in the management of graft-vs-host disease effects during the posttransplantation process. In this review, the role of different types of SCs is presented with regard to their application in SC transplantation. In addition to this, the therapeutic value of autologous and allogeneic hematopoietic stem–cell transplantation is assessed with respect to different types of leukemia. Highly advanced and progressive scientific research has focused on the application of stem-cell transplantation on specific leukemia types. We evaluated and compared the therapeutic potential of SC transplantation with various forms of leukemia. This review aimed to focus on the application of SCs in the treatment of leukemia.Keywords: stem cell, leukemia, transplantation
format	article
author	Dessie G Derbew Molla M Shibabaw T Ayelign B
author_facet	Dessie G Derbew Molla M Shibabaw T Ayelign B
author_sort	Dessie G
title	Role of Stem-Cell Transplantation in Leukemia Treatment
title_short	Role of Stem-Cell Transplantation in Leukemia Treatment
title_full	Role of Stem-Cell Transplantation in Leukemia Treatment
title_fullStr	Role of Stem-Cell Transplantation in Leukemia Treatment
title_full_unstemmed	Role of Stem-Cell Transplantation in Leukemia Treatment
title_sort	role of stem-cell transplantation in leukemia treatment
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fe997b6034ea485f8aa85ed211299be9
work_keys_str_mv	AT dessieg roleofstemcelltransplantationinleukemiatreatment AT derbewmollam roleofstemcelltransplantationinleukemiatreatment AT shibabawt roleofstemcelltransplantationinleukemiatreatment AT ayelignb roleofstemcelltransplantationinleukemiatreatment
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Role of Stem-Cell Transplantation in Leukemia Treatment

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