The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast.

The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast.

Centromeric heterochromatin assembly in fission yeast is critical for faithful chromosome segregation at mitosis. Its assembly requires a concerted pathway of events whereby the RNA interference (RNAi) pathway guides H3K9 methylation to target sequences. H3K9 methylation, a hallmark of heterochromat...

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Main Authors: Sharon A White, Alessia Buscaino, Luis Sanchez-Pulido, Chris P Ponting, Matthew W Nowicki, Robin C Allshire
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/fe99f6edba5e4be2b25ea62ae3b8bbd8
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